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HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH UC84

X-ray diffraction
3Å resolution
PDB entry 1rt7 coloured by chain, front view.
PDB entry 1rt7 coloured by chain, side view.
PDB entry 1rt7 coloured by chain, top view.
Source organism: HIV-1 M:B_HXB2R
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Protease
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Multimeric state: hetero dimer
Accessible surface area: 47063.7 Å2
Buried surface area: 5851.83 Å2
Dissociation area: 2,443.95 Å2
Dissociation energy (ΔGdiss): 17.52 kcal/mol
Dissociation entropy (TΔSdiss): 14.97 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138005

Macromolecules

Reverse transcriptase/ribonuclease H
Chain: A
Length: 560 amino acids
Theoretical weight: 64.59 KDa
Source organism: HIV-1 M:B_HXB2R
Expression system: Escherichia coli
UniProt:
  • Canonical: P04585 (Residues: 588-1147; Coverage: 39%)
Gene name: gag-pol
Pfam:
InterPro:
CATH:
SCOP:
Reverse transcriptase/ribonuclease H in PDB entry 1rt7, assembly 1, front view.
Reverse transcriptase/ribonuclease H in PDB entry 1rt7, assembly 1, side view.
Reverse transcriptase/ribonuclease H in PDB entry 1rt7, assembly 1, top view.
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p51 RT
Chain: B
Length: 440 amino acids
Theoretical weight: 51.4 KDa
Source organism: HIV-1 M:B_HXB2R
Expression system: Escherichia coli
UniProt:
  • Canonical: P04585 (Residues: 588-1027; Coverage: 31%)
Gene name: gag-pol
Pfam:
InterPro:
CATH:
SCOP: Reverse transcriptase
p51 RT in PDB entry 1rt7, assembly 1, front view.
p51 RT in PDB entry 1rt7, assembly 1, side view.
p51 RT in PDB entry 1rt7, assembly 1, top view.
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