EC 3.2.2.31: Adenine glycosylase
Reaction catalysed:
Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.
Systematic name:
Adenine-DNA deoxyribohydrolase (adenine-releasing)
Alternative Name(s):
- A/G-specific adenine glycosylase
- MutY (gene name)
GO terms
Biochemical function:
- 4 iron, 4 sulfur cluster binding
- metal ion binding
- adenine/guanine mispair binding
- 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
- oxidized purine DNA binding
- DNA N-glycosylase activity
- hydrolase activity, acting on glycosyl bonds
- catalytic activity
- DNA binding
- purine-specific mismatch base pair DNA N-glycosylase activity
Biological process:
Cellular component:
- not assigned
Sequence families
Protein families (Pfam)
![The deposited structure of PDB entry 1rrq contains 1 copy of Pfam domain PF14815 (NUDIX domain) in Adenine DNA glycosylase. Showing 1 copy in chain C [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/1rrq_3_A_Pfam_PF14815_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1rrq</span> contains 1 copy of Pfam domain <span class='highlight'>PF14815 (NUDIX domain)</span> in <span class='highlight'>Adenine DNA glycosylase</span>. Showing 1 copy in chain <span class='highlight'>C [auth A]</span>.")
![The deposited structure of PDB entry 1rrq contains 1 copy of Pfam domain PF10576 (Iron-sulfur binding domain of endonuclease III) in Adenine DNA glycosylase. Showing 1 copy in chain C [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/1rrq_3_A_Pfam_PF10576_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1rrq</span> contains 1 copy of Pfam domain <span class='highlight'>PF10576 (Iron-sulfur binding domain of endonuclease III)</span> in <span class='highlight'>Adenine DNA glycosylase</span>. Showing 1 copy in chain <span class='highlight'>C [auth A]</span>.")
![The deposited structure of PDB entry 1rrq contains 1 copy of Pfam domain PF00633 (Helix-hairpin-helix motif) in Adenine DNA glycosylase. Showing 1 copy in chain C [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/1rrq_3_A_Pfam_PF00633_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1rrq</span> contains 1 copy of Pfam domain <span class='highlight'>PF00633 (Helix-hairpin-helix motif)</span> in <span class='highlight'>Adenine DNA glycosylase</span>. Showing 1 copy in chain <span class='highlight'>C [auth A]</span>.")
![The deposited structure of PDB entry 1rrq contains 1 copy of Pfam domain PF00730 (HhH-GPD superfamily base excision DNA repair protein) in Adenine DNA glycosylase. Showing 1 copy in chain C [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/1rrq_3_A_Pfam_PF00730_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1rrq</span> contains 1 copy of Pfam domain <span class='highlight'>PF00730 (HhH-GPD superfamily base excision DNA repair protein)</span> in <span class='highlight'>Adenine DNA glycosylase</span>. Showing 1 copy in chain <span class='highlight'>C [auth A]</span>.")
InterPro annotations
Structure domains
CATH domains
1.10.1670.10
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Endonuclease Iii, domain 2
Homology:
Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)
Occurring in:
![The deposited structure of PDB entry 1rrq contains 1 copy of CATH domain 1.10.1670.10 (Endonuclease Iii, domain 2) in Adenine DNA glycosylase. Showing 1 copy in chain C [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/1rrq_3_A_CATH_1.10.1670.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1rrq</span> contains 1 copy of CATH domain <span class='highlight'>1.10.1670.10 (Endonuclease Iii, domain 2)</span> in <span class='highlight'>Adenine DNA glycosylase</span>. Showing 1 copy in chain <span class='highlight'>C [auth A]</span>.")
3.90.79.10
Class:
Alpha Beta
Architecture:
Alpha-Beta Complex
Topology:
Nucleoside Triphosphate Pyrophosphohydrolase
Homology:
Nucleoside Triphosphate Pyrophosphohydrolase
Occurring in:
![The deposited structure of PDB entry 1rrq contains 1 copy of CATH domain 3.90.79.10 (Nucleoside Triphosphate Pyrophosphohydrolase) in Adenine DNA glycosylase. Showing 1 copy in chain C [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/1rrq_3_A_CATH_3.90.79.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1rrq</span> contains 1 copy of CATH domain <span class='highlight'>3.90.79.10 (Nucleoside Triphosphate Pyrophosphohydrolase)</span> in <span class='highlight'>Adenine DNA glycosylase</span>. Showing 1 copy in chain <span class='highlight'>C [auth A]</span>.")
![The deposited structure of PDB entry 1rrq contains 1 copy of CATH domain 1.10.340.30 (Endonuclease III; domain 1) in Adenine DNA glycosylase. Showing 1 copy in chain C [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/1rrq_3_A_CATH_1.10.340.30_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1rrq</span> contains 1 copy of CATH domain <span class='highlight'>1.10.340.30 (Endonuclease III; domain 1)</span> in <span class='highlight'>Adenine DNA glycosylase</span>. Showing 1 copy in chain <span class='highlight'>C [auth A]</span>.")
SCOP annotations![The deposited structure of PDB entry 1rrq contains 1 copy of SCOP domain 103211 (MutY C-terminal domain-like) in Adenine DNA glycosylase. Showing 1 copy in chain C [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/1rrq_3_A_SCOP_103211_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1rrq</span> contains 1 copy of SCOP domain <span class='highlight'>103211 (MutY C-terminal domain-like)</span> in <span class='highlight'>Adenine DNA glycosylase</span>. Showing 1 copy in chain <span class='highlight'>C [auth A]</span>.")
![The deposited structure of PDB entry 1rrq contains 1 copy of SCOP domain 48154 (Mismatch glycosylase) in Adenine DNA glycosylase. Showing 1 copy in chain C [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/1rrq_3_A_SCOP_48154_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1rrq</span> contains 1 copy of SCOP domain <span class='highlight'>48154 (Mismatch glycosylase)</span> in <span class='highlight'>Adenine DNA glycosylase</span>. Showing 1 copy in chain <span class='highlight'>C [auth A]</span>.")