Structure analysis

deoxyhypusine synthase holoenzyme in its low ionic strength, high pH crystal form with the inhibitor GC7 bound in the active site

X-ray diffraction
3Å resolution
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo tetramer

Binding statistics and energies are not available for this assembly

Macromolecules

Chains: A, B
Length: 369 amino acids
Theoretical weight: 41.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P49366 (Residues: 1-369; Coverage: 100%)
Gene names: DHPS, DS
Pfam: Deoxyhypusine synthase
InterPro:
CATH: Deoxyhypusine synthase
SCOP: Deoxyhypusine synthase, DHS

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