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TWO BINDING ORIENTATIONS FOR PEPTIDES TO SRC SH3 DOMAIN: DEVELOPMENT OF A GENERAL MODEL FOR SH3-LIGAND INTERACTIONS

Solution NMR
PDB entry 1rlq coloured by chain, front view.
PDB entry 1rlq coloured by chain, side view.
PDB entry 1rlq coloured by chain, top view.
Source organism: Gallus gallus
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Proto-oncogene tyrosine-protein kinase Src and peptide
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Multimeric state: hetero dimer
Accessible surface area: 4930.25 Å2
Buried surface area: 723.63 Å2
Dissociation area: 361.82 Å2
Dissociation energy (ΔGdiss): -0.45 kcal/mol
Dissociation entropy (TΔSdiss): 7.16 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-132638

Macromolecules

Proto-oncogene tyrosine-protein kinase Src
Chain: C
Length: 64 amino acids
Theoretical weight: 7 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00523 (Residues: 77-140; Coverage: 12%)
Gene name: SRC
Pfam: SH3 domain
InterPro:
CATH: SH3 Domains
SCOP: SH3-domain
Proto-oncogene tyrosine-protein kinase Src in PDB entry 1rlq, assembly 1, front view.
Proto-oncogene tyrosine-protein kinase Src in PDB entry 1rlq, assembly 1, side view.
Proto-oncogene tyrosine-protein kinase Src in PDB entry 1rlq, assembly 1, top view.
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PROLINE-RICH LIGAND RLP2 (RALPPLPRY)
Chain: R
Length: 9 amino acids
Theoretical weight: 1.08 KDa
Source organism: Gallus gallus
Expression system: Not provided
PROLINE-RICH LIGAND RLP2 (RALPPLPRY) in PDB entry 1rlq, assembly 1, front view.
PROLINE-RICH LIGAND RLP2 (RALPPLPRY) in PDB entry 1rlq, assembly 1, side view.
PROLINE-RICH LIGAND RLP2 (RALPPLPRY) in PDB entry 1rlq, assembly 1, top view.
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