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Crystal structure of the complex of resistant strain of hiv-1 protease(v82a mutant) with ritonavir

X-ray diffraction
2Å resolution
PDB entry 1rl8 coloured by chain, front view.
PDB entry 1rl8 coloured by chain, side view.
PDB entry 1rl8 coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Protease
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Multimeric state: homo dimer
Accessible surface area: 8928.58 Å2
Buried surface area: 5201.86 Å2
Dissociation area: 2,216.41 Å2
Dissociation energy (ΔGdiss): 33.68 kcal/mol
Dissociation entropy (TΔSdiss): 11.47 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-136860

Macromolecules

Protease
Chains: A, B
Length: 99 amino acids
Theoretical weight: 10.69 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P03367 (Residues: 501-599; Coverage: 7%)
Gene name: gag-pol
Pfam: Retroviral aspartyl protease
InterPro:
CATH: Acid Proteases
Protease in PDB entry 1rl8, assembly 1, front view.
Protease in PDB entry 1rl8, assembly 1, side view.
Protease in PDB entry 1rl8, assembly 1, top view.
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