Structure analysis

Plasmodium falciparum peptide deformylase complex with inhibitor

X-ray diffraction
2.18Å resolution
Source organism: Plasmodium falciparum 3D7
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 8900 Å2
Buried surface area: 1300 Å2
Dissociation area: 350 Å2
Dissociation energy (ΔGdiss): -7 kcal/mol
Dissociation entropy (TΔSdiss): 6 kcal/mol
Interface energy (ΔGint): -7 kcal/mol
Symmetry number: 1
Assembly 2
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Multimeric state: monomeric
Accessible surface area: 9000 Å2
Buried surface area: 1300 Å2
Dissociation area: 350 Å2
Dissociation energy (ΔGdiss): -8 kcal/mol
Dissociation entropy (TΔSdiss): 6 kcal/mol
Interface energy (ΔGint): -8 kcal/mol
Symmetry number: 1

Macromolecules

Chains: A, B
Length: 188 amino acids
Theoretical weight: 22.27 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8I372 (Residues: 59-236; Coverage: 74%)
Gene name: PF3D7_0907900
Pfam: Polypeptide deformylase
InterPro:
CATH: Peptide deformylase
SCOP: Peptide deformylase

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