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S-Adenosylmethionine synthetase complexed with SAM and PPNP

Source organism: Escherichia coli
Biochemical function: metal ion binding
Biological process: S-adenosylmethionine cycle
Cellular component: cytosol

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EC 2.5.1.6: Methionine adenosyltransferase

Reaction catalysed:
ATP + L-methionine + H(2)O = phosphate + diphosphate + S-adenosyl-L-methionine
Systematic name:
ATP:L-methionine S-adenosyltransferase
Alternative Name(s):
  • ATP-methionine adenosyltransferase
  • Adenosylmethionine synthetase
  • AdoMet synthetase
  • Methionine S-adenosyltransferase
  • Methionine-activating enzyme
  • S-adenosyl-L-methionine synthetase
  • S-adenosylmethionine synthase
  • S-adenosylmethionine synthetase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02773
Domain description: S-adenosylmethionine synthetase, C-terminal domain
Occurring in:
  1. S-adenosylmethionine synthase
The deposited structure of PDB entry 1rg9 contains 4 copies of Pfam domain PF02773 (S-adenosylmethionine synthetase, C-terminal domain) in S-adenosylmethionine synthase. Showing 1 copy in chain A.

PF02772
Domain description: S-adenosylmethionine synthetase, central domain
Occurring in:
  1. S-adenosylmethionine synthase
The deposited structure of PDB entry 1rg9 contains 4 copies of Pfam domain PF02772 (S-adenosylmethionine synthetase, central domain) in S-adenosylmethionine synthase. Showing 1 copy in chain A.

PF00438
Domain description: S-adenosylmethionine synthetase, N-terminal domain
Occurring in:
  1. S-adenosylmethionine synthase
The deposited structure of PDB entry 1rg9 contains 4 copies of Pfam domain PF00438 (S-adenosylmethionine synthetase, N-terminal domain) in S-adenosylmethionine synthase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002133
Domain description: S-adenosylmethionine synthetase
Occurring in:
  1. S-adenosylmethionine synthase
IPR022636
Domain description: S-adenosylmethionine synthetase superfamily
Occurring in:
  1. S-adenosylmethionine synthase
IPR022631
Domain description: S-adenosylmethionine synthetase, conserved site
Occurring in:
  1. S-adenosylmethionine synthase
IPR022630
Domain description: S-adenosylmethionine synthetase, C-terminal
Occurring in:
  1. S-adenosylmethionine synthase
IPR022629
Domain description: S-adenosylmethionine synthetase, central domain
Occurring in:
  1. S-adenosylmethionine synthase
IPR022628
Domain description: S-adenosylmethionine synthetase, N-terminal
Occurring in:
  1. S-adenosylmethionine synthase

Structure domain

CATH CATH domain
3.30.300.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: GMP Synthetase; Chain A, domain 3
Homology: GMP Synthetase; Chain A, domain 3
Occurring in:
  1. S-adenosylmethionine synthase
The deposited structure of PDB entry 1rg9 contains 12 copies of CATH domain 3.30.300.10 (GMP Synthetase; Chain A, domain 3) in S-adenosylmethionine synthase. Showing 3 copies in chain A.
SCOP SCOP annotation
55974
Class: Alpha and beta proteins (a+b)
Fold: S-adenosylmethionine synthetase
Superfamily: S-adenosylmethionine synthetase
Occurring in:
  1. S-adenosylmethionine synthase
The deposited structure of PDB entry 1rg9 contains 12 copies of SCOP domain 55974 (S-adenosylmethionine synthetase) in S-adenosylmethionine synthase. Showing 3 copies in chain A.

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