X-ray diffraction
2Å resolution

CDK2 complex with a 4-alkynyl oxindole inhibitor

Source organism: Homo sapiens
Primary publication:
A new series of potent oxindole inhibitors of CDK2.
Bioorg. Med. Chem. Lett. 14 913-7 (2004)
PMID: 15012993

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Cyclin-dependent kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 298 amino acids
Theoretical weight: 33.98 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X8C
Spacegroup: P212121
Unit cell:
a: 53.88Å b: 71.962Å c: 72.779Å
α: 90° β: 90° γ: 90°
R R work R free
0.22 0.218 0.262
Expression system: Spodoptera frugiperda