1r4l

X-ray diffraction
3Å resolution

Inhibitor Bound Human Angiotensin Converting Enzyme-Related Carboxypeptidase (ACE2)

Released:

Function and Biology Details

Reaction catalysed:
Angiotensin II + H(2)O = angiotensin-(1-7) + L-phenylalanine
Biochemical function:
Biological process:
Cellular component:
Structure domain:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Processed angiotensin-converting enzyme 2 Chain: A
Molecule details ›
Chain: A
Length: 615 amino acids
Theoretical weight: 71 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9BYF1 (Residues: 1-615; Coverage: 76%)
Gene names: ACE2, UNQ868/PRO1885
Sequence domains: Angiotensin-converting enzyme
disordered segment of collectrin homology domain Chain: B
Molecule details ›
Chain: B
Length: 6 amino acids
Theoretical weight: 529 Da
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
disordered segment of collectrin homology domain Chain: C
Molecule details ›
Chain: C
Length: 20 amino acids
Theoretical weight: 1.72 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
disordered segment of collectrin homology domain Chain: D
Molecule details ›
Chain: D
Length: 18 amino acids
Theoretical weight: 1.55 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
disordered segment of collectrin homology domain Chain: E
Molecule details ›
Chain: E
Length: 14 amino acids
Theoretical weight: 1.21 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: C2
Unit cell:
a: 100.531Å b: 86.509Å c: 105.858Å
α: 90° β: 103.65° γ: 90°
R-values:
R R work R free
0.253 0.253 0.337
Expression system: Spodoptera frugiperda