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Crystal Structure of Androgen Receptor DNA-Binding Domain Bound to a Direct Repeat Response Element

X-ray diffraction
3.1Å resolution
PDB entry 1r4i coloured by chain, front view.
PDB entry 1r4i coloured by chain, side view.
PDB entry 1r4i coloured by chain, top view.
Source organism: Rattus norvegicus
Assembly composition:
hetero tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Androgen receptor and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 12567.72 Å2
Buried surface area: 5062.73 Å2
Dissociation area: 1,418.5 Å2
Dissociation energy (ΔGdiss): 42.34 kcal/mol
Dissociation entropy (TΔSdiss): 11.2 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-114497

Macromolecules

Androgen receptor
Chains: A, B
Length: 105 amino acids
Theoretical weight: 11.65 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P15207 (Residues: 533-637; Coverage: 12%)
Gene names: Ar, Nr3c4
Pfam: Zinc finger, C4 type (two domains)
InterPro:
CATH: Erythroid Transcription Factor GATA-1, subunit A
SCOP: Nuclear receptor
Androgen receptor in PDB entry 1r4i, assembly 1, front view.
Androgen receptor in PDB entry 1r4i, assembly 1, side view.
Androgen receptor in PDB entry 1r4i, assembly 1, top view.
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DNA chain C
Name: 5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*TP*CP*AP*AP*GP*AP*AP*CP*AP*G)-3'
Representative chains: C
Source organism: Rattus norvegicus [10116]
Expression system: Not provided
Length: 18 nucleotides
Theoretical weight: 5.51 KDa
5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*TP*CP*AP*AP*GP*AP*AP*CP*AP*G)-3' in PDB entry 1r4i, assembly 1, front view.
5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*TP*CP*AP*AP*GP*AP*AP*CP*AP*G)-3' in PDB entry 1r4i, assembly 1, side view.
5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*TP*CP*AP*AP*GP*AP*AP*CP*AP*G)-3' in PDB entry 1r4i, assembly 1, top view.
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DNA chain D
Name: 5'-D(*CP*TP*GP*TP*TP*CP*TP*TP*GP*AP*TP*GP*TP*TP*CP*TP*GP*G)-3'
Representative chains: D
Source organism: Rattus norvegicus [10116]
Expression system: Not provided
Length: 18 nucleotides
Theoretical weight: 5.52 KDa
5'-D(*CP*TP*GP*TP*TP*CP*TP*TP*GP*AP*TP*GP*TP*TP*CP*TP*GP*G)-3' in PDB entry 1r4i, assembly 1, front view.
5'-D(*CP*TP*GP*TP*TP*CP*TP*TP*GP*AP*TP*GP*TP*TP*CP*TP*GP*G)-3' in PDB entry 1r4i, assembly 1, side view.
5'-D(*CP*TP*GP*TP*TP*CP*TP*TP*GP*AP*TP*GP*TP*TP*CP*TP*GP*G)-3' in PDB entry 1r4i, assembly 1, top view.
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