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Structure of human alpha-galactosidase

X-ray diffraction
3.45Å resolution
PDB entry 1r47 coloured by chain, front view.
PDB entry 1r47 coloured by chain, side view.
PDB entry 1r47 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Alpha-galactosidase A
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Multimeric state: homo dimer
Accessible surface area: 32227.09 Å2
Buried surface area: 8431.05 Å2
Dissociation area: 1,062.72 Å2
Dissociation energy (ΔGdiss): 2.2 kcal/mol
Dissociation entropy (TΔSdiss): 14.23 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-138990

Macromolecules

Alpha-galactosidase A
Chains: A, B
Length: 398 amino acids
Theoretical weight: 45.39 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P06280 (Residues: 32-429; Coverage: 100%)
Gene name: GLA
Pfam:
InterPro:
CATH:
SCOP:
Alpha-galactosidase A in PDB entry 1r47, assembly 1, front view.
Alpha-galactosidase A in PDB entry 1r47, assembly 1, side view.
Alpha-galactosidase A in PDB entry 1r47, assembly 1, top view.
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