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Crystal structure of the cyanobacterial metallothionein repressor SmtB (C14S/C61S/C121S mutant) in the Zn2alpha5-form

Source organism: Synechococcus elongatus PCC 7942 = FACHB-805
Biochemical function: metal ion binding
Biological process: regulation of DNA-templated transcription
Cellular component: not assigned

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GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF01022
Domain description: Bacterial regulatory protein, arsR family
Occurring in:
  1. Transcriptional repressor SmtB
The deposited structure of PDB entry 1r22 contains 2 copies of Pfam domain PF01022 (Bacterial regulatory protein, arsR family) in Transcriptional repressor SmtB. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR001845
Domain description: HTH ArsR-type DNA-binding domain
Occurring in:
  1. Transcriptional repressor SmtB
IPR011991
Domain description: ArsR-like helix-turn-helix domain
Occurring in:
  1. Transcriptional repressor SmtB
IPR036390
Domain description: Winged helix DNA-binding domain superfamily
Occurring in:
  1. Transcriptional repressor SmtB
IPR036388
Domain description: Winged helix-like DNA-binding domain superfamily
Occurring in:
  1. Transcriptional repressor SmtB

Structure domain

CATH CATH domain
1.10.10.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Arc Repressor Mutant, subunit A
Homology: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Occurring in:
  1. Transcriptional repressor SmtB
The deposited structure of PDB entry 1r22 contains 2 copies of CATH domain 1.10.10.10 (Arc Repressor Mutant, subunit A) in Transcriptional repressor SmtB. Showing 1 copy in chain B.
SCOP SCOP annotation
46801
Class: All alpha proteins
Fold: DNA/RNA-binding 3-helical bundle
Superfamily: "Winged helix" DNA-binding domain
Occurring in:
  1. Transcriptional repressor SmtB
The deposited structure of PDB entry 1r22 contains 2 copies of SCOP domain 46801 (ArsR-like transcriptional regulators) in Transcriptional repressor SmtB. Showing 1 copy in chain B.

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