X-ray diffraction
2Å resolution

Aplysia ADP ribosyl cyclase with bound pyridylcarbinol and R5P


Function and Biology Details

Reactions catalysed:
(1a) NAD(+) = cyclic ADP-ribose + nicotinamide
(1a) NADP(+) = 2'-phospho-cyclic ADP-ribose + nicotinamide
Biological process:
Cellular component:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase Chains: A, B
Molecule details ›
Chains: A, B
Length: 258 amino acids
Theoretical weight: 29.58 KDa
Source organism: Aplysia californica
Expression system: Escherichia coli
  • Canonical: P29241 (Residues: 25-282; Coverage: 100%)
Sequence domains: ADP-ribosyl cyclase
Structure domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P21
Unit cell:
a: 70.293Å b: 58.349Å c: 72.368Å
α: 90° β: 100.7° γ: 90°
R R work R free
0.214 0.212 0.252
Expression system: Escherichia coli