› 1r14

X-ray diffraction
2.5Å resolution

Carbohydrate recognition and neck domains of surfactant protein A (Sp-A) containing samarium

Released:
DOI: 10.2210/pdb1r14/pdb
PDB 1r14 coloured by chain and viewed from the front.
PDB 1r14 coloured by chain and viewed from the side.
PDB 1r14 coloured by chain and viewed from the top.
Source organism: Rattus norvegicus
Primary publication:
Crystal structure of trimeric carbohydrate recognition and neck domains of surfactant protein A.
Head JF, Mealy TR, McCormack FX, Seaton BA
J. Biol. Chem. 278 43254-60 (2003)
PMID: 12913002

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pulmonary surfactant-associated protein A Chain: A
Molecule details ›
Chain: A
Length: 148 amino acids
Theoretical weight: 16.67 KDa
Source organism: Rattus norvegicus
Expression system: Trichoplusia
UniProt:
  • Canonical: P08427 (Residues: 101-248; Coverage: 65%)
Gene names: Sftp-1, Sftp1, Sftpa, Sftpa1
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

2 bound ligands:
Ligand SM 2 x SM
Ligand MES 1 x MES
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X8C
Spacegroup: P63
Unit cell:
a: 97.68Å b: 97.68Å c: 44.4Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.222 0.222 0.247
Expression system: Trichoplusia

Quick links

Citations

14 review citations

SP-A and SP-D: Dual Functioning Immune Molecules With Antiviral and Immunomodulatory Properties.
Watson et al. (2020)
13 more

1 mention without citation

Lung surfactant protein A (SP-A) interactions with model lung surfactant lipids and an SP-B fragment.
Sarker et al. (2011)