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1.1 Angstrom Resolution Structure of the Complex Between the Protein Inhibitor, OMTKY3, and the Serine Protease, Subtilisin Carlsberg

Source organisms:
Biochemical function: serine-type endopeptidase inhibitor activity
Biological process: proteolysis
Cellular component: not assigned

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EC 3.4.21.62: Subtilisin

Reaction catalysed:
Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.
Alternative Name(s):
  • ALK-enzyme
  • Alcalase
  • Alcalase 0.6L
  • Alcalase 2.5L
  • Bacillopeptidase A
  • Bacillopeptidase B
  • Bacillus subtilis alkaline proteinase
  • Bacillus subtilis alkaline proteinase bioprase
  • Bioprase AL 15
  • Bioprase APL 30
  • Colistinase
  • Esperase
  • Genenase I
  • Kazusase
  • Maxatase
  • Opticlean
  • Orientase 10B
  • Protease S
  • Protease VIII
  • Protease XXVII
  • Protin A 3L
  • SP 266
  • Savinase
  • Savinase 16.0L
  • Savinase 32.0 L EX
  • Savinase 4.0T
  • Savinase 8.0L
  • Subtilisin BL
  • Subtilisin DY
  • Subtilisin E
  • Subtilisin GX
  • Subtilisin J
  • Subtilisin S41
  • Subtilisin Sendai
  • Subtilopeptidase
  • Superase
  • Thermoase
  • Thermoase PC 10

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00050
Domain description: Kazal-type serine protease inhibitor domain
Occurring in:
  1. Ovomucoid
The deposited structure of PDB entry 1r0r contains 1 copy of Pfam domain PF00050 (Kazal-type serine protease inhibitor domain) in Ovomucoid. Showing 1 copy in chain B [auth I].

PF00082
Domain description: Subtilase family
Occurring in:
  1. Subtilisin Carlsberg
The deposited structure of PDB entry 1r0r contains 1 copy of Pfam domain PF00082 (Subtilase family) in Subtilisin Carlsberg. Showing 1 copy in chain A [auth E].

InterPro InterPro annotations
IPR002350
Domain description: Kazal domain
Occurring in:
  1. Ovomucoid
IPR015500
Domain description: Peptidase S8, subtilisin-related
Occurring in:
  1. Subtilisin Carlsberg
IPR001239
Domain description: Proteinase inhibitor I1, Kazal-type, metazoa
Occurring in:
  1. Ovomucoid
IPR036058
Domain description: Kazal domain superfamily
Occurring in:
  1. Ovomucoid
IPR023828
Domain description: Peptidase S8, subtilisin, Ser-active site
Occurring in:
  1. Subtilisin Carlsberg
IPR022398
Domain description: Peptidase S8, subtilisin, His-active site
Occurring in:
  1. Subtilisin Carlsberg
IPR023827
Domain description: Peptidase S8, subtilisin, Asp-active site
Occurring in:
  1. Subtilisin Carlsberg
IPR034202
Domain description: Subtilisin Carlsberg-like catalytic domain
Occurring in:
  1. Subtilisin Carlsberg
IPR000209
Domain description: Peptidase S8/S53 domain
Occurring in:
  1. Subtilisin Carlsberg
IPR036852
Domain description: Peptidase S8/S53 domain superfamily
Occurring in:
  1. Subtilisin Carlsberg

Structure domains

CATH CATH domains
3.30.60.30
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Wheat Germ Agglutinin (Isolectin 2); domain 1
Homology: Wheat Germ Agglutinin (Isolectin 2); domain 1
Occurring in:
  1. Ovomucoid
The deposited structure of PDB entry 1r0r contains 1 copy of CATH domain 3.30.60.30 (Wheat Germ Agglutinin (Isolectin 2); domain 1) in Ovomucoid. Showing 1 copy in chain B [auth I].
3.40.50.200
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Peptidase S8/S53 domain
Occurring in:
  1. Subtilisin Carlsberg
The deposited structure of PDB entry 1r0r contains 1 copy of CATH domain 3.40.50.200 (Rossmann fold) in Subtilisin Carlsberg. Showing 1 copy in chain A [auth E].
SCOP SCOP annotations
57468
Class: Small proteins
Fold: Kazal-type serine protease inhibitors
Superfamily: Kazal-type serine protease inhibitors
Occurring in:
  1. Ovomucoid
The deposited structure of PDB entry 1r0r contains 1 copy of SCOP domain 57468 (Ovomucoid domain III-like) in Ovomucoid. Showing 1 copy in chain B [auth I].
52744
Class: Alpha and beta proteins (a/b)
Fold: Subtilisin-like
Superfamily: Subtilisin-like
Occurring in:
  1. Subtilisin Carlsberg
The deposited structure of PDB entry 1r0r contains 1 copy of SCOP domain 52744 (Subtilases) in Subtilisin Carlsberg. Showing 1 copy in chain A [auth E].

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