› 1r0e

X-ray diffraction
2.25Å resolution

Glycogen synthase kinase-3 beta in complex with 3-indolyl-4-arylmaleimide inhibitor

Released:
DOI: 10.2210/pdb1r0e/pdb
PDB 1r0e coloured by chain and viewed from the front.
PDB 1r0e coloured by chain and viewed from the side.
PDB 1r0e coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Allard J, Nikolcheva T, Gong L, Wang J, Dunten P, Avnur Z, Waters R, Sun Q, Skinner B

Function and Biology Details

Reaction catalysed: 
ATP + [tau protein] = ADP + [tau protein] phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycogen synthase kinase-3 beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 391 amino acids
Theoretical weight: 43.6 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P49841 (Residues: 35-420; Coverage: 92%)
Gene name: GSK3B
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand FLC 2 x FLC
Ligand DFN 2 x DFN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: P212121
Unit cell:
a: 83.957Å b: 84.009Å c: 180.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.223 0.252
Expression system: Trichoplusia ni

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