› 1qxw

X-ray diffraction
1.67Å resolution

Function and Biology Details

Reaction catalysed: 
Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140896 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Methionine aminopeptidase Chain: A
Molecule details ›
Chain: A
Length: 252 amino acids
Theoretical weight: 27.54 KDa
Source organism: Staphylococcus aureus
Expression system: Escherichia coli
UniProt:
  • Canonical: P0A078 (Residues: 1-252; Coverage: 100%)
Gene names: SAV1888, map
Sequence domains: Metallopeptidase family M24
Structure domains: Creatinase/methionine aminopeptidase superfamily

Ligands and Environments

3 bound ligands:
Ligand CO 2 x CO
Ligand ACT 2 x ACT
Ligand M1C 1 x M1C
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: OTHER
Spacegroup: P21
Unit cell:
a: 40.993Å b: 76.843Å c: 41.935Å
α: 90° β: 104.19° γ: 90°
R-values:
R R work R free
0.159 0.158 0.185
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Metallo-aminopeptidase inhibitors.
Mucha et al. (2010)
1 more