1qw6

X-ray diffraction
2.1Å resolution

Rat neuronal nitric oxide synthase oxygenase domain in complex with N-omega-propyl-L-Arg.

Released:

Function and Biology Details

Reaction catalysed:
(1a) 2 L-arginine + 2 NADPH + 2 O(2) = 2 N(omega)-hydroxy-L-arginine + 2 NADP(+) + 2 H(2)O
Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nitric oxide synthase, brain Chain: A
Molecule details ›
Chain: A
Length: 420 amino acids
Theoretical weight: 48.58 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P29476 (Residues: 298-716; Coverage: 29%)
Gene names: Bnos, Nos1
Sequence domains: Nitric oxide synthase, oxygenase domain
Structure domains:

Ligands and Environments


Cofactor: Ligand H4B 1 x H4B

Cofactor: Ligand HEM 1 x HEM
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: C2221
Unit cell:
a: 45.004Å b: 108.899Å c: 164.767Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.195 0.243
Expression system: Escherichia coli