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STRUCTURE OF THE DOUBLE-STRANDED RNA-BINDING DOMAIN OF THE PROTEIN KINASE PKR REVEALS THE MOLECULAR BASIS OF ITS DSRNA-MEDIATED ACTIVATION

Solution NMR
PDB 1qu6 coloured by chain and viewed from the front.
PDB 1qu6 coloured by chain and viewed from the side.
PDB 1qu6 coloured by chain and viewed from the top.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric

Binding statistics and energies are not available for this assembly

Macromolecules

Interferon-induced, double-stranded RNA-activated protein kinase
Chain: A
Length: 179 amino acids
Theoretical weight: 19.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19525 (Residues: 1-170; Coverage: 31%)
Gene names: EIF2AK2, PKR, PRKR
Pfam: Double-stranded RNA binding motif
InterPro: Double-stranded RNA-binding domain
CATH: Double Stranded RNA Binding Domain
SCOP: Double-stranded RNA-binding domain (dsRBD)
PDB 1qu6 contains 1 copy of Interferon-induced, double-stranded RNA-activated protein kinase in assembly 1. This protein is highlighted and viewed from the front.
PDB 1qu6 contains 1 copy of Interferon-induced, double-stranded RNA-activated protein kinase in assembly 1. This protein is highlighted and viewed from the side.
PDB 1qu6 contains 1 copy of Interferon-induced, double-stranded RNA-activated protein kinase in assembly 1. This protein is highlighted and viewed from the top.
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