Structure analysis

STRUCTURE OF THE DOUBLE-STRANDED RNA-BINDING DOMAIN OF THE PROTEIN KINASE PKR REVEALS THE MOLECULAR BASIS OF ITS DSRNA-MEDIATED ACTIVATION

Solution NMR
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric

Binding statistics and energies are not available for this assembly

Macromolecules

Chain: A
Length: 179 amino acids
Theoretical weight: 19.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19525 (Residues: 1-170; Coverage: 31%)
Gene names: EIF2AK2, PKR, PRKR
Pfam: Double-stranded RNA binding motif
InterPro: Double-stranded RNA-binding domain
CATH: Double Stranded RNA Binding Domain
SCOP: Double-stranded RNA-binding domain (dsRBD)

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