X-ray diffraction
2.72Å resolution

AChE from Drosophila Melanogaster complex with tacrine derivative 9-(3-iodobenzylamino)-1,2,3,4-tetrahydroacridine


Function and Biology Details

Reaction catalysed:
Acetylcholine + H(2)O = choline + acetate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Acetylcholinesterase Chain: A
Molecule details ›
Chain: A
Length: 585 amino acids
Theoretical weight: 64.96 KDa
Source organism: Drosophila melanogaster
Expression system: Drosophila melanogaster
  • Canonical: P07140 (Residues: 39-623; Coverage: 96%)
Gene names: Ace, CG17907
Sequence domains: Carboxylesterase family
Structure domains: alpha/beta hydrolase

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: P43212
Unit cell:
a: 94.93Å b: 94.93Å c: 160.02Å
α: 90° β: 90° γ: 90°
R R work R free
0.22 0.22 0.265
Expression system: Drosophila melanogaster