› 1qjs

X-ray diffraction
2.9Å resolution

mammalian blood serum haemopexin glycosylated-native protein and in complex with its ligand haem

Released:
DOI: 10.2210/pdb1qjs/pdb
PDB 1qjs coloured by chain and viewed from the front.
PDB 1qjs coloured by chain and viewed from the side.
PDB 1qjs coloured by chain and viewed from the top.
Source organism: Oryctolagus cuniculus
Primary publication:
Crystal structure of hemopexin reveals a novel high-affinity heme site formed between two beta-propeller domains.
Paoli M, Anderson BF, Baker HM, Morgan WT, Smith A, Baker EN
Nat. Struct. Biol. 6 926-31 (1999)
PMID: 10504726

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hemopexin Chains: A, B
Molecule details ›
Chains: A, B
Length: 460 amino acids
Theoretical weight: 51.83 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P20058 (Residues: 1-460; Coverage: 100%)
Gene name: HPX
Sequence domains: Hemopexin
Structure domains: Hemopexin-like domain

Ligands and Environments

4 bound ligands:
Ligand HEM 2 x HEM
Ligand PO4 2 x PO4
Ligand CL 4 x CL
Ligand NA 8 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 103.9Å b: 69.9Å c: 151.81Å
α: 90° β: 108.16° γ: 90°
R-values:
R R work R free
0.251 0.255 0.312

Quick links

Citations

42 review citations

DAMPs and Innate Immune Training.
Jentho et al. (2021)
41 more

4 mentions without citation

New knowledge from old: in silico discovery of novel protein domains in Streptomyces coelicolor.
Yeats et al. (2003)
3 more