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CRYSTAL STRUCTURE OF RIBONUCLEASE A IN COMPLEX WITH 5'-PHOSPHO-2'-DEOXYURIDINE-3'-PYROPHOSPHATE ADENOSINE-3'-PHOSPHATE

X-ray diffraction
1.7Å resolution
PDB entry 1qhc coloured by chain, front view.
PDB entry 1qhc coloured by chain, side view.
PDB entry 1qhc coloured by chain, top view.
Source organism: Bos taurus
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Ribonuclease pancreatic
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Multimeric state: monomeric
Accessible surface area: 6703.23 Å2
Buried surface area: 971.48 Å2
Dissociation area: 485.74 Å2
Dissociation energy (ΔGdiss): -0.81 kcal/mol
Dissociation entropy (TΔSdiss): 6.44 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158390
Assembly 2
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Assembly Name: Ribonuclease pancreatic
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Multimeric state: monomeric
Accessible surface area: 6751.32 Å2
Buried surface area: 1000.42 Å2
Dissociation area: 500.21 Å2
Dissociation energy (ΔGdiss): 1.48 kcal/mol
Dissociation entropy (TΔSdiss): 6.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158390

Macromolecules

Ribonuclease pancreatic
Chains: A, B
Length: 124 amino acids
Theoretical weight: 13.71 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P61823 (Residues: 27-150; Coverage: 100%)
Gene names: RNASE1, RNS1
Pfam: Pancreatic ribonuclease
InterPro:
CATH: Ribonuclease A-like domain
SCOP: Ribonuclease A-like
Ribonuclease pancreatic in PDB entry 1qhc, assembly 1, front view.
Ribonuclease pancreatic in PDB entry 1qhc, assembly 1, side view.
Ribonuclease pancreatic in PDB entry 1qhc, assembly 1, top view.
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