Function and Biology

BACTERIAL CHITOBIASE COMPLEXED WITH CHITOBIOSE (DINAG)

Source organism: Serratia marcescens
Biochemical function: hydrolase activity, hydrolyzing O-glycosyl compounds
Biological process: chitin catabolic process
Cellular component: periplasmic space

EC 3.2.1.52: Beta-N-acetylhexosaminidase

Reaction catalysed:
Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides
Systematic name:
Beta-N-acetyl-D-hexosaminide N-acetylhexosaminohydrolase
Alternative Name(s):
  • Beta-D-N-acetylhexosaminidase
  • Beta-D-hexosaminidase
  • Beta-N-acetyl-D-hexosaminidase
  • Beta-N-acetylglucosaminidase
  • Beta-acetylaminodeoxyhexosidase
  • Beta-acetylhexosaminidinase
  • Beta-hexosaminidase
  • Hexosaminidase
  • Hexosaminidase A
  • N-acetyl-beta-D-hexosaminidase
  • N-acetyl-beta-glucosaminidase
  • N-acetyl-beta-hexosaminidase
  • N-acetylhexosaminidase

Sequence families

Pfam Protein families (Pfam)
PF03174
Domain description: Chitobiase/beta-hexosaminidase C-terminal domain
Occurring in:
  1. Chitobiase
1 copy of Pfam domain PF03174 (Chitobiase/beta-hexosaminidase C-terminal domain) in Chitobiase in PDB 1qbb.

PF03173
Domain description: Putative carbohydrate binding domain
Occurring in:
  1. Chitobiase
1 copy of Pfam domain PF03173 (Putative carbohydrate binding domain) in Chitobiase in PDB 1qbb.

PF02838
Domain description: Glycosyl hydrolase family 20, domain 2
Occurring in:
  1. Chitobiase
1 copy of Pfam domain PF02838 (Glycosyl hydrolase family 20, domain 2) in Chitobiase in PDB 1qbb.

PF00728
Domain description: Glycosyl hydrolase family 20, catalytic domain
Occurring in:
  1. Chitobiase
1 copy of Pfam domain PF00728 (Glycosyl hydrolase family 20, catalytic domain) in Chitobiase in PDB 1qbb.

InterPro InterPro annotations
IPR025705
Domain description: Beta-hexosaminidase
Occurring in:
  1. Chitobiase
IPR004866
Domain description: Chitobiase/beta-hexosaminidases, N-terminal domain
Occurring in:
  1. Chitobiase
IPR004867
Domain description: Chitobiase C-terminal domain
Occurring in:
  1. Chitobiase
IPR029018
Domain description: Beta-hexosaminidase-like, domain 2
Occurring in:
  1. Chitobiase
IPR008965
Domain description: CBM2/CBM3, carbohydrate-binding domain superfamily
Occurring in:
  1. Chitobiase
IPR014756
Domain description: Immunoglobulin E-set
Occurring in:
  1. Chitobiase
IPR017853
Domain description: Glycoside hydrolase superfamily
Occurring in:
  1. Chitobiase
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Chitobiase
IPR012291
Domain description: CBM2, carbohydrate-binding domain superfamily
Occurring in:
  1. Chitobiase
IPR015883
Domain description: Glycoside hydrolase family 20, catalytic domain
Occurring in:
  1. Chitobiase
IPR015882
Domain description: Beta-hexosaminidase, bacterial type, N-terminal
Occurring in:
  1. Chitobiase

Structure domains

CATH CATH domains
3.30.379.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Chitobiase; domain 2
Homology: Chitobiase/beta-hexosaminidase domain 2-like
Occurring in:
  1. Chitobiase
1 copy of CATH domain 3.30.379.10 (Chitobiase; domain 2) in Chitobiase in PDB 1qbb.
3.20.20.80
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Glycosidases
Occurring in:
  1. Chitobiase
1 copy of CATH domain 3.20.20.80 (TIM Barrel) in Chitobiase in PDB 1qbb.
2.60.40.290
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulin-like
Occurring in:
  1. Chitobiase
1 copy of CATH domain 2.60.40.290 (Immunoglobulin-like) in Chitobiase in PDB 1qbb.
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Chitobiase
1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in Chitobiase in PDB 1qbb.
SCOP SCOP annotations
49398
Class: All beta proteins
Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
Superfamily: Carbohydrate-binding domain
Occurring in:
  1. Chitobiase
1 copy of SCOP domain 49398 (Bacterial chitobiase, n-terminal domain) in Chitobiase in PDB 1qbb.
51550
Class: Alpha and beta proteins (a/b)
Fold: TIM beta/alpha-barrel
Superfamily: (Trans)glycosidases
Occurring in:
  1. Chitobiase
1 copy of SCOP domain 51550 (beta-N-acetylhexosaminidase catalytic domain) in Chitobiase in PDB 1qbb.
55546
Class: Alpha and beta proteins (a+b)
Fold: Zincin-like
Superfamily: beta-N-acetylhexosaminidase-like domain
Occurring in:
  1. Chitobiase
1 copy of SCOP domain 55546 (beta-N-acetylhexosaminidase domain) in Chitobiase in PDB 1qbb.
81282
Class: All beta proteins
Fold: Immunoglobulin-like beta-sandwich
Superfamily: E set domains
Occurring in:
  1. Chitobiase
1 copy of SCOP domain 81282 (E-set domains of sugar-utilizing enzymes) in Chitobiase in PDB 1qbb.