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Crystal structure of a truncated form of FkpA from Escherichia coli, in complex with immunosuppressant FK506

Source organism: Escherichia coli
Biochemical function: protein folding chaperone
Biological process: protein refolding
Cellular component: periplasmic space

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EC 5.2.1.8: Peptidylprolyl isomerase

Reaction catalysed:
Peptidylproline (omega=180) = peptidylproline (omega=0)
Systematic name:
Peptidylproline cis-trans-isomerase
Alternative Name(s):
  • Cyclophilin
  • PPIase
  • Peptide bond isomerase
  • Peptidyl-prolyl cis-trans isomerase
  • Peptidylprolyl cis-trans isomerase
  • Rotamase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00254
Domain description: FKBP-type peptidyl-prolyl cis-trans isomerase
Occurring in:
  1. FKBP-type peptidyl-prolyl cis-trans isomerase FkpA
The deposited structure of PDB entry 1q6i contains 2 copies of Pfam domain PF00254 (FKBP-type peptidyl-prolyl cis-trans isomerase) in FKBP-type peptidyl-prolyl cis-trans isomerase FkpA. Showing 1 copy in chain A.

PF01346
Domain description: Domain amino terminal to FKBP-type peptidyl-prolyl isomerase
Occurring in:
  1. FKBP-type peptidyl-prolyl cis-trans isomerase FkpA
The deposited structure of PDB entry 1q6i contains 2 copies of Pfam domain PF01346 (Domain amino terminal to FKBP-type peptidyl-prolyl isomerase) in FKBP-type peptidyl-prolyl cis-trans isomerase FkpA. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001179
Domain description: FKBP-type peptidyl-prolyl cis-trans isomerase domain
Occurring in:
  1. FKBP-type peptidyl-prolyl cis-trans isomerase FkpA
IPR046357
Domain description: Peptidyl-prolyl cis-trans isomerase domain superfamily
Occurring in:
  1. FKBP-type peptidyl-prolyl cis-trans isomerase FkpA
IPR000774
Domain description: Peptidyl-prolyl cis-trans isomerase, FKBP-type, N-terminal
Occurring in:
  1. FKBP-type peptidyl-prolyl cis-trans isomerase FkpA
IPR036944
Domain description: Peptidyl-prolyl cis-trans isomerase, FKBP-type, N-terminal domain superfamily
Occurring in:
  1. FKBP-type peptidyl-prolyl cis-trans isomerase FkpA

Structure domains

CATH CATH domains
3.10.50.40
Class: Alpha Beta
Architecture: Roll
Topology: Chitinase A; domain 3
Homology: Chitinase A; domain 3
Occurring in:
  1. FKBP-type peptidyl-prolyl cis-trans isomerase FkpA
The deposited structure of PDB entry 1q6i contains 2 copies of CATH domain 3.10.50.40 (Chitinase A; domain 3) in FKBP-type peptidyl-prolyl cis-trans isomerase FkpA. Showing 1 copy in chain A.
1.10.287.460
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Helix Hairpins
Homology: Peptidyl-prolyl cis-trans isomerase, FKBP-type, N-terminal domain
Occurring in:
  1. FKBP-type peptidyl-prolyl cis-trans isomerase FkpA
The deposited structure of PDB entry 1q6i contains 2 copies of CATH domain 1.10.287.460 (Helix Hairpins) in FKBP-type peptidyl-prolyl cis-trans isomerase FkpA. Showing 1 copy in chain A.
SCOP SCOP annotation
54535
Class: Alpha and beta proteins (a+b)
Fold: FKBP-like
Superfamily: FKBP-like
Occurring in:
  1. FKBP-type peptidyl-prolyl cis-trans isomerase FkpA
The deposited structure of PDB entry 1q6i contains 2 copies of SCOP domain 54535 (FKBP immunophilin/proline isomerase) in FKBP-type peptidyl-prolyl cis-trans isomerase FkpA. Showing 1 copy in chain A.

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