› 1q4l

X-ray diffraction
2.77Å resolution

GSK-3 Beta complexed with Inhibitor I-5

Released:
DOI: 10.2210/pdb1q4l/pdb
PDB 1q4l coloured by chain and viewed from the front.
PDB 1q4l coloured by chain and viewed from the side.
PDB 1q4l coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Structural characterization of the GSK-3beta active site using selective and non-selective ATP-mimetic inhibitors.
Bertrand JA, Thieffine S, Vulpetti A, Cristiani C, Valsasina B, Knapp S, Kalisz HM, Flocco M
J. Mol. Biol. 333 393-407 (2003)
PMID: 14529625

Function and Biology Details

Reaction catalysed: 
ATP + [tau protein] = ADP + [tau protein] phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycogen synthase kinase-3 beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 424 amino acids
Theoretical weight: 47.08 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P49841 (Residues: 2-420; Coverage: 100%)
Gene name: GSK3B
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 679 2 x 679
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P212121
Unit cell:
a: 84.167Å b: 86.664Å c: 178.65Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.212 0.251
Expression system: Spodoptera frugiperda

Quick links

Citations

10 review citations

GSK-3β, FYN, and DYRK1A: Master Regulators in Neurodegenerative Pathways.
Demuro et al. (2021)
9 more

26 mentions without citation

Recent Developments in New Therapeutic Agents against Alzheimer and Parkinson Diseases: In-Silico Approaches.
Cruz-Vicente et al. (2021)
25 more