Structure analysis

Crystal structure of the Shank PDZ-ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerization

X-ray diffraction
1.8Å resolution
Source organism: Rattus norvegicus
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 11500 Å2
Buried surface area: 2100 Å2
Dissociation area: 700 Å2
Dissociation energy (ΔGdiss): 11 kcal/mol
Dissociation entropy (TΔSdiss): 11 kcal/mol
Interface energy (ΔGint): -67 kcal/mol
Symmetry number: 2

Macromolecules

Chains: A, B
Length: 109 amino acids
Theoretical weight: 12.07 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9WV48 (Residues: 654-762; Coverage: 5%)
Gene name: Shank1
Pfam: PDZ domain
InterPro:
CATH: Pdz3 Domain
SCOP: PDZ domain

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