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Crystal Structure of the ATP-bound E. coli MalK

Source organism: Escherichia coli K-12
Biochemical function: ABC-type transporter activity
Biological process: maltose transmembrane transport
Cellular component: enzyme IIA-maltose transporter complex

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EC 7.5.2.1: ABC-type maltose transporter

Reaction catalysed:
ATP + H(2)O + maltose-[maltose-binding protein](Side 1) = ADP + phosphate + maltose(Side 2) + [maltose-binding protein](Side 1)
Systematic name:
ATP phosphohydrolase (ABC-type, maltose-importing)
Alternative Name(s):
  • Maltose ABC transporter
  • Maltose-transporting ATPase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF08402
Domain description: TOBE domain
Occurring in:
  1. Maltose/maltodextrin import ATP-binding protein MalK

PF00005
Domain description: ABC transporter
Occurring in:
  1. Maltose/maltodextrin import ATP-binding protein MalK
The deposited structure of PDB entry 1q12 contains 4 copies of Pfam domain PF00005 (ABC transporter) in Maltose/maltodextrin import ATP-binding protein MalK. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003439
Domain description: ABC transporter-like, ATP-binding domain
Occurring in:
  1. Maltose/maltodextrin import ATP-binding protein MalK
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Maltose/maltodextrin import ATP-binding protein MalK
IPR012340
Domain description: Nucleic acid-binding, OB-fold
Occurring in:
  1. Maltose/maltodextrin import ATP-binding protein MalK
IPR008995
Domain description: Molybdate/tungstate binding, C-terminal
Occurring in:
  1. Maltose/maltodextrin import ATP-binding protein MalK
IPR040582
Domain description: MalK-like, OB fold domain
Occurring in:
  1. Maltose/maltodextrin import ATP-binding protein MalK
IPR017871
Domain description: ABC transporter-like, conserved site
Occurring in:
  1. Maltose/maltodextrin import ATP-binding protein MalK
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. Maltose/maltodextrin import ATP-binding protein MalK
IPR015855
Domain description: ABC transporter, maltose/maltodextrin import, MalK-like
Occurring in:
  1. Maltose/maltodextrin import ATP-binding protein MalK
IPR047641
Domain description: ABC transporter, ATP-binding protein MalK/UgpC-like
Occurring in:
  1. Maltose/maltodextrin import ATP-binding protein MalK

Structure domains

CATH CATH domains
2.40.50.100
Class: Mainly Beta
Architecture: Beta Barrel
Topology: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homology: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Occurring in:
  1. Maltose/maltodextrin import ATP-binding protein MalK
The deposited structure of PDB entry 1q12 contains 4 copies of CATH domain 2.40.50.100 (OB fold (Dihydrolipoamide Acetyltransferase, E2P)) in Maltose/maltodextrin import ATP-binding protein MalK. Showing 1 copy in chain A.
2.40.50.140
Class: Mainly Beta
Architecture: Beta Barrel
Topology: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homology: Nucleic acid-binding proteins
Occurring in:
  1. Maltose/maltodextrin import ATP-binding protein MalK
The deposited structure of PDB entry 1q12 contains 4 copies of CATH domain 2.40.50.140 (OB fold (Dihydrolipoamide Acetyltransferase, E2P)) in Maltose/maltodextrin import ATP-binding protein MalK. Showing 1 copy in chain A.
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Maltose/maltodextrin import ATP-binding protein MalK
The deposited structure of PDB entry 1q12 contains 4 copies of CATH domain 3.40.50.300 (Rossmann fold) in Maltose/maltodextrin import ATP-binding protein MalK. Showing 1 copy in chain A.
SCOP SCOP annotations
50338
Class: All beta proteins
Fold: OB-fold
Superfamily: MOP-like
Occurring in:
  1. Maltose/maltodextrin import ATP-binding protein MalK
The deposited structure of PDB entry 1q12 contains 4 copies of SCOP domain 50338 (ABC-transporter additional domain) in Maltose/maltodextrin import ATP-binding protein MalK. Showing 1 copy in chain A.
52686
Class: Alpha and beta proteins (a/b)
Fold: P-loop containing nucleoside triphosphate hydrolases
Superfamily: P-loop containing nucleoside triphosphate hydrolases
Occurring in:
  1. Maltose/maltodextrin import ATP-binding protein MalK
The deposited structure of PDB entry 1q12 contains 4 copies of SCOP domain 52686 (ABC transporter ATPase domain-like) in Maltose/maltodextrin import ATP-binding protein MalK. Showing 1 copy in chain A.

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