› › Structure analysis

HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR 4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-ylamine

X-ray diffraction
2.3Å resolution
PDB entry 1pxj coloured by chain, front view.
PDB entry 1pxj coloured by chain, side view.
PDB entry 1pxj coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Cyclin-dependent kinase 2
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 14293.14 Å2
Buried surface area: 507.39 Å2
Dissociation area: 253.7 Å2
Dissociation energy (ΔGdiss): -3.48 kcal/mol
Dissociation entropy (TΔSdiss): 2.97 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150313

Macromolecules

Cyclin-dependent kinase 2
Chain: A
Length: 298 amino acids
Theoretical weight: 33.98 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Pfam: Protein kinase domain
InterPro:
CATH:
SCOP: Protein kinases, catalytic subunit
Cyclin-dependent kinase 2 in PDB entry 1pxj, assembly 1, front view.
Cyclin-dependent kinase 2 in PDB entry 1pxj, assembly 1, side view.
Cyclin-dependent kinase 2 in PDB entry 1pxj, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links