› 1prx

X-ray diffraction
2Å resolution

HORF6 A NOVEL HUMAN PEROXIDASE ENZYME

Released:
DOI: 10.2210/pdb1prx/pdb
PDB 1prx coloured by chain and viewed from the front.
PDB 1prx coloured by chain and viewed from the side.
PDB 1prx coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Crystal structure of a novel human peroxidase enzyme at 2.0 A resolution.
Choi HJ, Kang SW, Yang CH, Rhee SG, Ryu SE
Nat. Struct. Biol. 5 400-6 (1998)
PMID: 9587003

Function and Biology Details

Reactions catalysed: 
2 glutathione + ROOH = glutathione disulfide + H(2)O + ROH
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxiredoxin-6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 224 amino acids
Theoretical weight: 25.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P30041 (Residues: 1-224; Coverage: 100%)
Gene names: AOP2, KIAA0106, PRDX6
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand CSO 2 x CSO

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P21
Unit cell:
a: 47.85Å b: 75.17Å c: 63.3Å
α: 90° β: 110.21° γ: 90°
R-values:
R R work R free
0.191 0.191 0.259
Expression system: Escherichia coli

Quick links

Citations

49 review citations

Peroxiredoxins wear many hats: Factors that fashion their peroxide sensing personalities.
Bolduc et al. (2021)
48 more

29 mentions without citation

Peroxiredoxins and Redox Signaling in Plants.
Liebthal et al. (2018)
28 more