1prh

X-ray diffraction
3.5Å resolution

THE X-RAY CRYSTAL STRUCTURE OF THE MEMBRANE PROTEIN PROSTAGLANDIN H2 SYNTHASE-1

Released:
Source organism: Ovis aries

Function and Biology Details

Reaction catalysed:
Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O
Biochemical function:
Biological process:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Prostaglandin G/H synthase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 554 amino acids
Theoretical weight: 63.87 KDa
Source organism: Ovis aries
Expression system: Not provided
UniProt:
  • Canonical: P05979 (Residues: 33-586; Coverage: 96%)
Gene names: COX1, PTGS1
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand HEM 2 x HEM
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: I222
Unit cell:
a: 99.4Å b: 210.3Å c: 233.1Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.267 0.267 0.316
Expression system: Not provided