PDBe 1pr9

X-ray diffraction
1.96Å resolution

Human L-Xylulose Reductase Holoenzyme

Released:

Function and Biology Details

Reaction catalysed:
Xylitol + NADP(+) = L-xylulose + NADPH
Biological process:
Cellular component:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
L-xylulose reductase Chains: A, B
Molecule details ›
Chains: A, B
Length: 244 amino acids
Theoretical weight: 25.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q7Z4W1 (Residues: 1-244; Coverage: 100%)
Gene names: DCXR, SDR20C1
Sequence domains: Enoyl-(Acyl carrier protein) reductase
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments


Cofactor: Ligand NAP 2 x NAP
2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P21212
Unit cell:
a: 74.111Å b: 87.938Å c: 72.883Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.178 0.227
Expression system: Escherichia coli BL21