Solution NMR

Solution Structure of the MutT Pyrophosphohydrolase Complexed with Mg(2+) and 8-oxo-dGMP, a Tightly-bound Product


Function and Biology Details

Reaction catalysed:
8-oxo-dGTP + H(2)O = 8-oxo-dGMP + diphosphate
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
8-oxo-dGTP diphosphatase Chain: A
Molecule details ›
Chain: A
Length: 129 amino acids
Theoretical weight: 14.95 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
  • Canonical: P08337 (Residues: 1-129; Coverage: 100%)
Gene names: JW0097, b0099, mutT
Structure domains: Nucleoside Triphosphate Pyrophosphohydrolase

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing torsion angle dynamics
Chemical shifts: BMR5866  
Expression system: Escherichia coli