PDBe 1ppg

X-ray diffraction
2.3Å resolution

The refined 2.3 angstroms crystal structure of human leukocyte elastase in a complex with a valine chloromethyl ketone inhibitor


Function and Biology Details

Reaction catalysed:
Hydrolysis of proteins, including elastin. Preferential cleavage Val-|- > Ala-|-.
Biochemical function:
Cellular component:

Structure analysis Details

Assemblies composition:
hetero hexamer
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Neutrophil elastase Chain: E
Molecule details ›
Chain: E
Length: 218 amino acids
Theoretical weight: 23.32 KDa
Source organism: Homo sapiens
  • Canonical: P08246 (Residues: 30-247; Coverage: 91%)
Gene names: ELA2, ELANE
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Molecule details ›
Chain: I
Length: 6 amino acids
Theoretical weight: 507 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P63
Unit cell:
a: 74.2Å b: 74.2Å c: 70.6Å
α: 90° β: 90° γ: 120°
R R work R free
0.145 0.145 not available
Expression system: Not provided