EC 3.4.21.37: Leukocyte elastase
Reaction catalysed:
Hydrolysis of proteins, including elastin. Preferential cleavage Val-|- > Ala-|-.
Systematic name:
-
Alternative Name(s):
- Bone marrow serine protease
- Elastase
- Elaszym
- Granulocyte elastase
- Lysosomal elastase
- Medullasin
- Neutrophil elastase
- Polymorphonuclear leukocyte elastase
- Serine elastase
GO terms
Biochemical function:
Biological process:
- positive regulation of leukocyte tethering or rolling
- neutrophil-mediated killing of fungus
- neutrophil-mediated killing of gram-negative bacterium
- pyroptosis
- negative regulation of chemotaxis
- leukocyte migration
- defense response to fungus
- positive regulation of immune response
- negative regulation of inflammatory response
- positive regulation of smooth muscle cell proliferation
- positive regulation of MAP kinase activity
- defense response to bacterium
- positive regulation of interleukin-8 production
- negative regulation of interleukin-8 production
- negative regulation of chemokine production
- response to lipopolysaccharide
- protein catabolic process
- extracellular matrix disassembly
- response to UV
- phagocytosis
- intracellular calcium ion homeostasis
- proteolysis
- biosynthetic process of antibacterial peptides active against Gram-negative bacteria
- leukocyte migration involved in inflammatory response
- acute inflammatory response to antigenic stimulus
- response to yeast
- negative regulation of transcription by RNA polymerase II
Cellular component:
Sequence families
Protein families (Pfam)
![The deposited structure of PDB entry 1ppf contains 1 copy of Pfam domain PF00050 (Kazal-type serine protease inhibitor domain) in Ovomucoid. Showing 1 copy in chain B [auth I].](https://www.ebi.ac.uk/pdbe/static/entry/1ppf_2_I_Pfam_PF00050_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1ppf</span> contains 1 copy of Pfam domain <span class='highlight'>PF00050 (Kazal-type serine protease inhibitor domain)</span> in <span class='highlight'>Ovomucoid</span>. Showing 1 copy in chain <span class='highlight'>B [auth I]</span>.")
![The deposited structure of PDB entry 1ppf contains 1 copy of Pfam domain PF00089 (Trypsin) in Neutrophil elastase. Showing 1 copy in chain A [auth E].](https://www.ebi.ac.uk/pdbe/static/entry/1ppf_1_E_Pfam_PF00089_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1ppf</span> contains 1 copy of Pfam domain <span class='highlight'>PF00089 (Trypsin)</span> in <span class='highlight'>Neutrophil elastase</span>. Showing 1 copy in chain <span class='highlight'>A [auth E]</span>.")
InterPro annotations
Structure domains
CATH domains
2.40.10.10
Class:
Mainly Beta
Architecture:
Beta Barrel
Topology:
Thrombin, subunit H
Homology:
Trypsin-like serine proteases
Occurring in:
![The deposited structure of PDB entry 1ppf contains 2 copies of CATH domain 2.40.10.10 (Thrombin, subunit H) in Neutrophil elastase. Showing 2 copies in chain A [auth E].](https://www.ebi.ac.uk/pdbe/static/entry/1ppf_1_E_CATH_2.40.10.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1ppf</span> contains 2 copies of CATH domain <span class='highlight'>2.40.10.10 (Thrombin, subunit H)</span> in <span class='highlight'>Neutrophil elastase</span>. Showing 2 copies in chain <span class='highlight'>A [auth E]</span>.")
![The deposited structure of PDB entry 1ppf contains 1 copy of CATH domain 3.30.60.30 (Wheat Germ Agglutinin (Isolectin 2); domain 1) in Ovomucoid. Showing 1 copy in chain B [auth I].](https://www.ebi.ac.uk/pdbe/static/entry/1ppf_2_I_CATH_3.30.60.30_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1ppf</span> contains 1 copy of CATH domain <span class='highlight'>3.30.60.30 (Wheat Germ Agglutinin (Isolectin 2); domain 1)</span> in <span class='highlight'>Ovomucoid</span>. Showing 1 copy in chain <span class='highlight'>B [auth I]</span>.")
SCOP annotations![The deposited structure of PDB entry 1ppf contains 1 copy of SCOP domain 57468 (Ovomucoid domain III-like) in Ovomucoid. Showing 1 copy in chain B [auth I].](https://www.ebi.ac.uk/pdbe/static/entry/1ppf_2_I_SCOP_57468_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1ppf</span> contains 1 copy of SCOP domain <span class='highlight'>57468 (Ovomucoid domain III-like)</span> in <span class='highlight'>Ovomucoid</span>. Showing 1 copy in chain <span class='highlight'>B [auth I]</span>.")
![The deposited structure of PDB entry 1ppf contains 1 copy of SCOP domain 50514 (Eukaryotic proteases) in Neutrophil elastase. Showing 1 copy in chain A [auth E].](https://www.ebi.ac.uk/pdbe/static/entry/1ppf_1_E_SCOP_50514_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1ppf</span> contains 1 copy of SCOP domain <span class='highlight'>50514 (Eukaryotic proteases)</span> in <span class='highlight'>Neutrophil elastase</span>. Showing 1 copy in chain <span class='highlight'>A [auth E]</span>.")