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THE REFINED 2.0 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF THE COMPLEX FORMED BETWEEN BOVINE BETA-TRYPSIN AND CMTI-I, A TRYPSIN INHIBITOR FROM SQUASH SEEDS (CUCURBITA MAXIMA): TOPOLOGICAL SIMILARITY OF THE SQUASH SEED INHIBITORS WITH THE CARBOXYPEPTIDASE A INHIBITOR FROM POTATOES

X-ray diffraction
2Å resolution
PDB entry 1ppe coloured by chain, front view.
PDB entry 1ppe coloured by chain, side view.
PDB entry 1ppe coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Serine protease 1 and Trypsin inhibitor 1
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Multimeric state: hetero dimer
Accessible surface area: 9918.74 Å2
Buried surface area: 1684.38 Å2
Dissociation area: 842.19 Å2
Dissociation energy (ΔGdiss): 5.5 kcal/mol
Dissociation entropy (TΔSdiss): 9.3 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133328

Macromolecules

Serine protease 1
Chain: E
Length: 223 amino acids
Theoretical weight: 23.32 KDa
Source organism: Bos taurus
Expression system: Not provided
UniProt:
  • Canonical: P00760 (Residues: 24-246; Coverage: 97%)
Gene names: PRSS1, TRP1, TRY1, TRYP1
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
SCOP: Eukaryotic proteases
Serine protease 1 in PDB entry 1ppe, assembly 1, front view.
Serine protease 1 in PDB entry 1ppe, assembly 1, side view.
Serine protease 1 in PDB entry 1ppe, assembly 1, top view.
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Trypsin inhibitor 1
Chain: I
Length: 29 amino acids
Theoretical weight: 3.28 KDa
Source organism: Cucurbita maxima
Expression system: Not provided
UniProt:
  • Canonical: P01074 (Residues: 1-29; Coverage: 100%)
Pfam: Squash family serine protease inhibitor
InterPro:
SCOP: Plant inhibitors of proteinases and amylases
Trypsin inhibitor 1 in PDB entry 1ppe, assembly 1, front view.
Trypsin inhibitor 1 in PDB entry 1ppe, assembly 1, side view.
Trypsin inhibitor 1 in PDB entry 1ppe, assembly 1, top view.
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