Structure analysis

Mouse Importin alpha-bipartite NLS from human retinoblastoma protein Complex

X-ray diffraction
2.5Å resolution
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 18700 Å2
Buried surface area: 2600 Å2
Dissociation area: 1,300 Å2
Dissociation energy (ΔGdiss): 3 kcal/mol
Dissociation entropy (TΔSdiss): 9 kcal/mol
Interface energy (ΔGint): -1 kcal/mol
Symmetry number: 1

Macromolecules

Chain: A
Length: 20 amino acids
Theoretical weight: 2.13 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P06400 (Residues: 858-877; Coverage: null%)
Gene name: RB1

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Chain: B
Length: 460 amino acids
Theoretical weight: 49.89 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P52293 (Residues: 70-529; Coverage: null%)
Gene names: Kpna2, Rch1
InterPro:
CATH: Leucine-rich Repeat Variant
SCOP: Armadillo repeat

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