X-ray diffraction
2.5Å resolution

Mouse Importin alpha-bipartite NLS from human retinoblastoma protein Complex


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Retinoblastoma-associated protein Chain: A
Molecule details ›
Chain: A
Length: 20 amino acids
Theoretical weight: 2.13 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: P06400 (Residues: 858-877; Coverage: 2%)
Gene name: RB1
Importin subunit alpha-1 Chain: B
Molecule details ›
Chain: B
Length: 460 amino acids
Theoretical weight: 49.89 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
  • Canonical: P52293 (Residues: 70-529; Coverage: 87%)
Gene names: Kpna2, Rch1
Sequence domains:
Structure domains: Leucine-rich Repeat Variant

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 79Å b: 89.179Å c: 100.992Å
α: 90° β: 90° γ: 90°
R R work R free
0.204 0.204 0.239
Expression systems:
  • Not provided
  • Escherichia coli