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PHOSPHATIDYLINOSITOL 3-KINASE, P85-ALPHA SUBUNIT: C-TERMINAL SH2 DOMAIN COMPLEXED WITH A TYR751 PHOSPHOPEPTIDE FROM THE PDGF RECEPTOR, NMR, MINIMIZED MEAN STRUCTURE

Solution NMR
PDB entry 1pic coloured by chain, front view.
PDB entry 1pic coloured by chain, side view.
PDB entry 1pic coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Phosphatidylinositol 3-kinase regulatory subunit alpha and peptide
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Multimeric state: hetero dimer
Accessible surface area: 7401.78 Å2
Buried surface area: 1369.81 Å2
Dissociation area: 620.23 Å2
Dissociation energy (ΔGdiss): 6.95 kcal/mol
Dissociation entropy (TΔSdiss): 6.59 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-151136

Macromolecules

Phosphatidylinositol 3-kinase regulatory subunit alpha
Chain: A
Length: 112 amino acids
Theoretical weight: 12.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P27986 (Residues: 616-724; Coverage: 15%)
Gene names: GRB1, PIK3R1
Pfam: SH2 domain
InterPro:
CATH: SH2 domain
SCOP: SH2 domain
Phosphatidylinositol 3-kinase regulatory subunit alpha in PDB entry 1pic, assembly 1, front view.
Phosphatidylinositol 3-kinase regulatory subunit alpha in PDB entry 1pic, assembly 1, side view.
Phosphatidylinositol 3-kinase regulatory subunit alpha in PDB entry 1pic, assembly 1, top view.
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BETA-PLATELET-DERIVED GROWTH FACTOR RECEPTOR
Chain: B
Length: 6 amino acids
Theoretical weight: 728 Da
Source organism: Homo sapiens
Expression system: Not provided
BETA-PLATELET-DERIVED GROWTH FACTOR RECEPTOR in PDB entry 1pic, assembly 1, front view.
BETA-PLATELET-DERIVED GROWTH FACTOR RECEPTOR in PDB entry 1pic, assembly 1, side view.
BETA-PLATELET-DERIVED GROWTH FACTOR RECEPTOR in PDB entry 1pic, assembly 1, top view.
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