PDBe 1p9m

X-ray diffraction
3.65Å resolution

Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Interleukin-6 receptor subunit beta Chain: A
Molecule details ›
Chain: A
Length: 299 amino acids
Theoretical weight: 34.1 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P40189 (Residues: 23-321; Coverage: 33%)
Gene name: IL6ST
Sequence domains:
Structure domains: Immunoglobulins
Interleukin-6 Chain: B
Molecule details ›
Chain: B
Length: 186 amino acids
Theoretical weight: 21.1 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P05231 (Residues: 29-212; Coverage: 100%)
Gene names: IFNB2, IL6
Structure domains: Growth Hormone; Chain: A;
Interleukin-6 receptor subunit alpha Chain: C
Molecule details ›
Chain: C
Length: 201 amino acids
Theoretical weight: 23.05 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P08887 (Residues: 115-315; Coverage: 45%)
Gene name: IL6R
Sequence domains: Interleukin-6 receptor alpha chain, binding
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: R32
Unit cell:
a: 279.8Å b: 279.8Å c: 96.7Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.282 0.282 0.334
Expression system: Spodoptera frugiperda