X-ray diffraction
2.5Å resolution

Guanidinoacetate Methyltransferase with Gd ion

Source organism: Rattus norvegicus
Primary publication:
Monoclinic guanidinoacetate methyltransferase and gadolinium ion-binding characteristics.
Acta Crystallogr. D Biol. Crystallogr. 59 1589-96 (2003)
PMID: 12925789

Function and Biology Details

Reaction catalysed:
S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Guanidinoacetate N-methyltransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 199 amino acids
Theoretical weight: 22.62 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
  • Canonical: P10868 (Residues: 38-236; Coverage: 84%)
Gene name: Gamt
Structure domains: Vaccinia Virus protein VP39

Ligands and Environments

Cofactor: Ligand SAH 2 x SAH
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P43
Unit cell:
a: 54.22Å b: 54.22Å c: 156.27Å
α: 90° β: 90° γ: 90°
R R work R free
0.211 0.193 0.288
Expression system: Escherichia coli