1ox1

X-ray diffraction
2Å resolution

crystal structure of the bovine trypsin complex with a synthetic 11 peptide inhibitor

Released:
Source organism: Bos taurus
Entry authors: Wu G, Huang Y, Zhu G, Huang Q, Tang Y, Miyake H, Kusunoki M

Function and Biology Details

Reaction catalysed:
Preferential cleavage: Arg-|-, Lys-|-.
Biochemical function:
Biological process:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Serine protease 1 Chain: A
Molecule details ›
Chain: A
Length: 223 amino acids
Theoretical weight: 23.32 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00760 (Residues: 24-246; Coverage: 97%)
Gene names: PRSS1, TRP1, TRY1, TRYP1
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
11-mer peptide Chain: B
Molecule details ›
Chain: B
Length: 11 amino acids
Theoretical weight: 1.26 KDa
Source organism: Bos taurus
Expression system: Not provided

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 63.7Å b: 63.14Å c: 69.47Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.165 0.162 0.185
Expression system: Not provided