› 1owx

Solution NMR

Solution structure of the C-terminal RRM of human La (La225-334)

Released:
DOI: 10.2210/pdb1owx/pdb
PDB entry 1owx coloured by chain, ensemble of 20 models, front view.
PDB entry 1owx coloured by chain, ensemble of 20 models, side view.
PDB entry 1owx coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the C-terminal domain of human La protein reveals a novel RNA recognition motif coupled to a helical nuclear retention element.
Jacks A, Babon J, Kelly G, Manolaridis I, Cary PD, Curry S, Conte MR
Structure 11 833-43 (2003)
PMID: 12842046

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138679 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lupus La protein Chain: A
Molecule details ›
Chain: A
Length: 121 amino acids
Theoretical weight: 13.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05455 (Residues: 225-334; Coverage: 27%)
Gene name: SSB
Sequence domains: RNA binding motif
Structure domains: Alpha-Beta Plaits

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

14 review citations

RNA-binding proteins: modular design for efficient function.
Lunde et al. (2007)
13 more

19 mentions without citation

The La and related RNA-binding proteins (LARPs): structures, functions, and evolving perspectives.
Maraia et al. (2017)
18 more