1ov4

X-ray diffraction
2.7Å resolution

Crystal structure of human DHEA-ST complexed with androsterone

Released:

Function and Biology Details

Reaction catalysed:
3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sulfotransferase 2A1 Chain: A
Molecule details ›
Chain: A
Length: 293 amino acids
Theoretical weight: 34.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q06520 (Residues: 2-285; Coverage: 100%)
Gene names: HST, STD, SULT2A1
Sequence domains: Sulfotransferase domain
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X8C
Spacegroup: P21212
Unit cell:
a: 75.293Å b: 129.818Å c: 44.287Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.23 0.27
Expression system: Escherichia coli