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Human Hsp90 in complex with 17-desmethoxy-17-N,N-Dimethylaminoethylamino-Geldanamycin

X-ray diffraction
1.75Å resolution
PDB entry 1osf coloured by chain, front view.
PDB entry 1osf coloured by chain, side view.
PDB entry 1osf coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Heat shock protein HSP 90-alpha
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Multimeric state: monomeric
Accessible surface area: 11445.44 Å2
Buried surface area: 1372.16 Å2
Dissociation area: 517.66 Å2
Dissociation energy (ΔGdiss): -3.44 kcal/mol
Dissociation entropy (TΔSdiss): 5.74 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139817

Macromolecules

Heat shock protein HSP 90-alpha
Chain: A
Length: 215 amino acids
Theoretical weight: 24.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07900 (Residues: 9-223; Coverage: 29%)
Gene names: HSP90A, HSP90AA1, HSPC1, HSPCA
Pfam: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
InterPro:
CATH: Histidine kinase-like ATPase, C-terminal domain
SCOP: Heat shock protein 90, HSP90, N-terminal domain
Heat shock protein HSP 90-alpha in PDB entry 1osf, assembly 1, front view.
Heat shock protein HSP 90-alpha in PDB entry 1osf, assembly 1, side view.
Heat shock protein HSP 90-alpha in PDB entry 1osf, assembly 1, top view.
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