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THE CRYSTAL STRUCTURE OF THE OROTATE PHOSPHORIBOSYLTRANSFERASE COMPLEXED WITH OROTATE AND ALPHA-D-5-PHOSPHORIBOSYL-1-PYROPHOSPHATE

Source organism: Salmonella enterica subsp. enterica serovar Typhimurium
Biochemical function: glycosyltransferase activity
Biological process: pyrimidine-containing compound biosynthetic process
Cellular component: cytoplasm

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EC 2.4.2.10: Orotate phosphoribosyltransferase

Reaction catalysed:
Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate
Systematic name:
Orotidine-5'-phosphate:diphosphate phospho-alpha-D-ribosyl-transferase
Alternative Name(s):
  • OPRT
  • OPRTase
  • Orotate phosphoribosyl pyrophosphate transferase
  • Orotic acid phosphoribosyltransferase
  • Orotidine 5'-monophosphate pyrophosphorylase
  • Orotidine monophosphate pyrophosphorylase
  • Orotidine phosphoribosyltransferase
  • Orotidine-5'-phosphate diphosphorylase
  • Orotidine-5'-phosphate pyrophosphorylase
  • Orotidylate phosphoribosyltransferase
  • Orotidylate pyrophosphorylase
  • Orotidylic acid phosphorylase
  • Orotidylic acid pyrophosphorylase
  • Orotidylic phosphorylase
  • Orotidylic pyrophosphorylase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00156
Domain description: Phosphoribosyl transferase domain
Occurring in:
  1. Orotate phosphoribosyltransferase
The deposited structure of PDB entry 1opr contains 1 copy of Pfam domain PF00156 (Phosphoribosyl transferase domain) in Orotate phosphoribosyltransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000836
Domain description: Phosphoribosyltransferase domain
Occurring in:
  1. Orotate phosphoribosyltransferase
IPR029057
Domain description: Phosphoribosyltransferase-like
Occurring in:
  1. Orotate phosphoribosyltransferase
IPR004467
Domain description: Orotate phosphoribosyl transferase domain
Occurring in:
  1. Orotate phosphoribosyltransferase
IPR023031
Domain description: Orotate phosphoribosyltransferase
Occurring in:
  1. Orotate phosphoribosyltransferase

Structure domain

CATH CATH domain
3.40.50.2020
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Orotate phosphoribosyltransferase
The deposited structure of PDB entry 1opr contains 1 copy of CATH domain 3.40.50.2020 (Rossmann fold) in Orotate phosphoribosyltransferase. Showing 1 copy in chain A.
SCOP SCOP annotation
53272
Class: Alpha and beta proteins (a/b)
Fold: PRTase-like
Superfamily: PRTase-like
Occurring in:
  1. Orotate phosphoribosyltransferase
The deposited structure of PDB entry 1opr contains 1 copy of SCOP domain 53272 (Phosphoribosyltransferases (PRTases)) in Orotate phosphoribosyltransferase. Showing 1 copy in chain A.

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