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Human brain neuroglobin structure reveals a distinct mode of controlling oxygen affinity.

Pesce A, Dewilde S, Nardini M, Moens L, Ascenzi P, Hankeln T, Burmester T, Bolognesi M
Structure 11 1087-95 (2003)
Cited: 177 times
EuropePMC logo PMID: 12962627

Reviews - 1oj6 mentioned but not cited (6)

  1. Neuroglobin, a Factor Playing for Nerve Cell Survival. Guidolin D, Tortorella C, Marcoli M, Maura G, Agnati LF. Int J Mol Sci 17 (2016)
  2. Conservation of the three-dimensional structure in non-homologous or unrelated proteins. Sousounis K, Haney CE, Cao J, Sunchu B, Tsonis PA. Hum. Genomics 6 10 (2012)
  3. Ligand-Based Regulation of Dynamics and Reactivity of Hemoproteins. Turilli-Ghisolfi ES, Lualdi M, Fasano M. Biomolecules 13 683 (2023)
  4. Role of cytoglobin, a novel radical scavenger, in stellate cell activation and hepatic fibrosis. Thuy LTT, Hai H, Kawada N. Clin Mol Hepatol 26 280-293 (2020)
  5. Simple mechanisms for the evolution of protein complexity. Pillai AS, Hochberg GKA, Thornton JW. Protein Sci 31 e4449 (2022)
  6. Structural and (Pseudo-)Enzymatic Properties of Neuroglobin: Its Possible Role in Neuroprotection. De Simone G, Sbardella D, Oddone F, Pesce A, Coletta M, Ascenzi P. Cells 10 3366 (2021)

Articles - 1oj6 mentioned but not cited (18)

  1. Human neuroglobin functions as a redox-regulated nitrite reductase. Tiso M, Tejero J, Basu S, Azarov I, Wang X, Simplaceanu V, Frizzell S, Jayaraman T, Geary L, Shapiro C, Ho C, Shiva S, Kim-Shapiro DB, Gladwin MT. J. Biol. Chem. 286 18277-18289 (2011)
  2. Reactivity and endogenous modification by nitrite and hydrogen peroxide: does human neuroglobin act only as a scavenger? Nicolis S, Monzani E, Ciaccio C, Ascenzi P, Moens L, Casella L. Biochem. J. 407 89-99 (2007)
  3. Identification of protein radicals formed in the human neuroglobin-H2O2 reaction using immuno-spin trapping and mass spectrometry. Lardinois OM, Tomer KB, Mason RP, Deterding LJ. Biochemistry 47 10440-10448 (2008)
  4. Ligand migration through the internal hydrophobic cavities in human neuroglobin. Abbruzzetti S, Faggiano S, Bruno S, Spyrakis F, Mozzarelli A, Dewilde S, Moens L, Viappiani C. Proc. Natl. Acad. Sci. U.S.A. 106 18984-18989 (2009)
  5. Structural characterization of ferric hemoglobins from three antarctic fish species of the suborder notothenioidei. Vergara A, Franzese M, Merlino A, Vitagliano L, Verde C, di Prisco G, Lee HC, Peisach J, Mazzarella L. Biophys. J. 93 2822-2829 (2007)
  6. Exploring the mechanisms of the reductase activity of neuroglobin by site-directed mutagenesis of the heme distal pocket. Tejero J, Sparacino-Watkins CE, Ragireddy V, Frizzell S, Gladwin MT. Biochemistry 54 722-733 (2015)
  7. Simultaneous Bayesian estimation of alignment and phylogeny under a joint model of protein sequence and structure. Herman JL, Challis CJ, Novák Á, Hein J, Schmidler SC. Mol Biol Evol 31 2251-2266 (2014)
  8. Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning. Azarov I, Wang L, Rose JJ, Xu Q, Huang XN, Belanger A, Wang Y, Guo L, Liu C, Ucer KB, McTiernan CF, O'Donnell CP, Shiva S, Tejero J, Kim-Shapiro DB, Gladwin MT. Sci Transl Med 8 368ra173 (2016)
  9. DEER Sensitivity between Iron Centers and Nitroxides in Heme-Containing Proteins Improves Dramatically Using Broadband, High-Field EPR. Motion CL, Lovett JE, Bell S, Cassidy SL, Cruickshank PA, Bolton DR, Hunter RI, El Mkami H, Van Doorslaer S, Smith GM. J Phys Chem Lett 7 1411-1415 (2016)
  10. Biophysical characterisation of neuroglobin of the icefish, a natural knockout for hemoglobin and myoglobin. Comparison with human neuroglobin. Giordano D, Boron I, Abbruzzetti S, Van Leuven W, Nicoletti FP, Forti F, Bruno S, Cheng CH, Moens L, di Prisco G, Nadra AD, Estrin D, Smulevich G, Dewilde S, Viappiani C, Verde C. PLoS ONE 7 e44508 (2012)
  11. Heme orientation modulates histidine dissociation and ligand binding kinetics in the hexacoordinated human neuroglobin. Bocahut A, Derrien V, Bernad S, Sebban P, Sacquin-Mora S, Guittet E, Lescop E. J. Biol. Inorg. Chem. 18 111-122 (2013)
  12. Crucial roles of Glu60 in human neuroglobin as a guanine nucleotide dissociation inhibitor and neuroprotective agent. Takahashi N, Watanabe S, Wakasugi K. PLoS ONE 8 e83698 (2013)
  13. A possible mechanism for redox control of human neuroglobin activity. Morozov AN, Roach JP, Kotzer M, Chatfield DC. J Chem Inf Model 54 1997-2003 (2014)
  14. Efficient Reduction of Vertebrate Cytoglobins by the Cytochrome b5/Cytochrome b5 Reductase/NADH System. Amdahl MB, Sparacino-Watkins CE, Corti P, Gladwin MT, Tejero J. Biochemistry 56 3993-4004 (2017)
  15. The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins. Chakraborty S, Rendón-Ramírez A, Ásgeirsson B, Dutta M, Ghosh AS, Oda M, Venkatramani R, Rao BJ, Dandekar AM, Goñi FM. F1000Res 2 286 (2013)
  16. Phylogeny of Echinoderm Hemoglobins. Christensen AB, Herman JL, Elphick MR, Kober KM, Janies D, Linchangco G, Semmens DC, Bailly X, Vinogradov SN, Hoogewijs D. PLoS ONE 10 e0129668 (2015)
  17. Chimeric ZHHH neuroglobin acts as a cell membrane-penetrating inducer of neurite outgrowth. Takahashi N, Onozuka W, Watanabe S, Wakasugi K. FEBS Open Bio 7 1338-1349 (2017)
  18. Engineering neuroglobin nitrite reductase activity based on myoglobin models. Williams MD, Ragireddy V, Dent MR, Tejero J. Biochem Biophys Rep 36 101560 (2023)


Reviews citing this publication (29)

  1. Neuroglobin: a respiratory protein of the nervous system. Burmester T, Hankeln T. News Physiol. Sci. 19 110-113 (2004)
  2. Structure and reactivity of hexacoordinate hemoglobins. Kakar S, Hoffman FG, Storz JF, Fabian M, Hargrove MS. Biophys. Chem. 152 1-14 (2010)
  3. A globin for the brain. Brunori M, Vallone B. FASEB J. 20 2192-2197 (2006)
  4. The respiratory proteins of insects. Burmester T, Hankeln T. J. Insect Physiol. 53 285-294 (2007)
  5. Structural divergence and distant relationships in proteins: evolution of the globins. Lecomte JT, Vuletich DA, Lesk AM. Curr. Opin. Struct. Biol. 15 290-301 (2005)
  6. Neuroprotective roles and mechanisms of neuroglobin. Yu Z, Fan X, Lo EH, Wang X. Neurol. Res. 31 122-127 (2009)
  7. An antiapoptotic neuroprotective role for neuroglobin. Brittain T, Skommer J, Raychaudhuri S, Birch N. Int J Mol Sci 11 2306-2321 (2010)
  8. A role for human neuroglobin in apoptosis. Brittain T, Skommer J, Henty K, Birch N, Raychaudhuri S. IUBMB Life 62 878-885 (2010)
  9. Neuroglobin, a novel target for endogenous neuroprotection against stroke and neurodegenerative disorders. Yu Z, Liu N, Liu J, Yang K, Wang X. Int J Mol Sci 13 6995-7014 (2012)
  10. Mycobacterial truncated hemoglobins: from genes to functions. Ascenzi P, Bolognesi M, Milani M, Guertin M, Visca P. Gene 398 42-51 (2007)
  11. Mammalian nerve globins in search of functions. Ascenzi P, Gustincich S, Marino M. IUBMB Life 66 268-276 (2014)
  12. Neuroglobin: From structure to function in health and disease. Ascenzi P, di Masi A, Leboffe L, Fiocchetti M, Nuzzo MT, Brunori M, Marino M. Mol. Aspects Med. 52 1-48 (2016)
  13. Structure and function of heme proteins in non-native states: a mini-review. Lin YW, Wang J. J. Inorg. Biochem. 129 162-171 (2013)
  14. The globin superfamily: functions in nitric oxide formation and decay. Tejero J, Gladwin MT. Biol. Chem. 395 631-639 (2014)
  15. The heme environment of mouse neuroglobin: histidine imidazole plane orientations obtained from solution NMR and EPR spectroscopy as compared with X-ray crystallography. Walker FA. J. Biol. Inorg. Chem. 11 391-397 (2006)
  16. Neuroglobin, estrogens, and neuroprotection. De Marinis E, Marino M, Ascenzi P. IUBMB Life 63 140-145 (2011)
  17. Regulatory Fe(II/III) heme: the reconstruction of a molecule's biography. Kühl T, Imhof D. Chembiochem 15 2024-2035 (2014)
  18. Growth Factors and Neuroglobin in Astrocyte Protection Against Neurodegeneration and Oxidative Stress. Cabezas R, Baez-Jurado E, Hidalgo-Lanussa O, Echeverria V, Ashrad GM, Sahebkar A, Barreto GE. Mol Neurobiol 56 2339-2351 (2019)
  19. Protective actions of 17β-estradiol and progesterone on oxidative neuronal injury induced by organometallic compounds. Ishihara Y, Takemoto T, Ishida A, Yamazaki T. Oxid Med Cell Longev 2015 343706 (2015)
  20. Brain globins in physiology and pathology. Xie LK, Yang SH. Med Gas Res 6 154-163 (2016)
  21. Protein self-modification by heme-generated reactive species. Monzani E, Nicolis S, Roncone R, Barbieri M, Granata A, Casella L. IUBMB Life 60 41-56 (2008)
  22. Redox and Peroxidase Activities of the Hemoglobin Superfamily: Relevance to Health and Disease. Reeder BJ. Antioxid. Redox Signal. 26 763-776 (2017)
  23. Neuroglobin and friends. Fiocchetti M, Cipolletti M, Brandi V, Polticelli F, Ascenzi P. J. Mol. Recognit. 30 (2017)
  24. Neuroglobin Expression in the Brain: a Story of Tissue Homeostasis Preservation. Van Acker ZP, Luyckx E, Dewilde S. Mol. Neurobiol. 56 2101-2122 (2019)
  25. Structural analysis in nonsymbiotic hemoglobins: what can we learn from inner cavities? Spyrakis F, Luque FJ, Viappiani C. Plant Sci. 181 8-13 (2011)
  26. Tertiary and quaternary effects in the allosteric regulation of animal hemoglobins. Ronda L, Bruno S, Bettati S. Biochim. Biophys. Acta 1834 1860-1872 (2013)
  27. The role of globins in cardiovascular physiology. Keller TCS, Lechauve C, Keller AS, Brooks S, Weiss MJ, Columbus L, Ackerman H, Cortese-Krott MM, Isakson BE. Physiol Rev 102 859-892 (2022)
  28. Molecular Interactions between Neuroglobin and Cytochrome c: Possible Mechanisms of Antiapoptotic Defense in Neuronal Cells. Semenova MA, Chertkova RV, Kirpichnikov MP, Dolgikh DA. Biomolecules 13 1233 (2023)
  29. Neuroglobin: A Novel Player in the Oxidative Stress Response of Cancer Cells. Fiocchetti M, Fernandez VS, Montalesi E, Marino M. Oxid Med Cell Longev 2019 6315034 (2019)

Articles citing this publication (124)

  1. Reactivity studies of the Fe(III) and Fe(II)NO forms of human neuroglobin reveal a potential role against oxidative stress. Herold S, Fago A, Weber RE, Dewilde S, Moens L. J. Biol. Chem. 279 22841-22847 (2004)
  2. The redox state of the cell regulates the ligand binding affinity of human neuroglobin and cytoglobin. Hamdane D, Kiger L, Dewilde S, Green BN, Pesce A, Uzan J, Burmester T, Hankeln T, Bolognesi M, Moens L, Marden MC. J. Biol. Chem. 278 51713-51721 (2003)
  3. Design and engineering of an O(2) transport protein. Koder RL, Anderson JL, Solomon LA, Reddy KS, Moser CC, Dutton PL. Nature 458 305-309 (2009)
  4. Neuroglobin and cytoglobin overexpression protects human SH-SY5Y neuroblastoma cells against oxidative stress-induced cell death. Fordel E, Thijs L, Martinet W, Lenjou M, Laufs T, Van Bockstaele D, Moens L, Dewilde S. Neurosci. Lett. 410 146-151 (2006)
  5. Allosteric regulation and temperature dependence of oxygen binding in human neuroglobin and cytoglobin. Molecular mechanisms and physiological significance. Fago A, Hundahl C, Dewilde S, Gilany K, Moens L, Weber RE. J. Biol. Chem. 279 44417-44426 (2004)
  6. A molecular basis for NO selectivity in soluble guanylate cyclase. Boon EM, Huang SH, Marletta MA. Nat. Chem. Biol. 1 53-59 (2005)
  7. The structure of murine neuroglobin: Novel pathways for ligand migration and binding. Vallone B, Nienhaus K, Brunori M, Nienhaus GU. Proteins 56 85-92 (2004)
  8. Crystal structure of cytoglobin: the fourth globin type discovered in man displays heme hexa-coordination. de Sanctis D, Dewilde S, Pesce A, Moens L, Ascenzi P, Hankeln T, Burmester T, Bolognesi M. J. Mol. Biol. 336 917-927 (2004)
  9. Neuroglobin protects nerve cells from apoptosis by inhibiting the intrinsic pathway of cell death. Raychaudhuri S, Skommer J, Henty K, Birch N, Brittain T. Apoptosis 15 401-411 (2010)
  10. Reactions of ferrous neuroglobin and cytoglobin with nitrite under anaerobic conditions. Petersen MG, Dewilde S, Fago A. J. Inorg. Biochem. 102 1777-1782 (2008)
  11. Cytoglobin expression is upregulated in all tissues upon hypoxia: an in vitro and in vivo study by quantitative real-time PCR. Fordel E, Geuens E, Dewilde S, Rottiers P, Carmeliet P, Grooten J, Moens L. Biochem. Biophys. Res. Commun. 319 342-348 (2004)
  12. The amphibian globin gene repertoire as revealed by the Xenopus genome. Fuchs C, Burmester T, Hankeln T. Cytogenet. Genome Res. 112 296-306 (2006)
  13. Structural basis of human cytoglobin for ligand binding. Sugimoto H, Makino M, Sawai H, Kawada N, Yoshizato K, Shiro Y. J. Mol. Biol. 339 873-885 (2004)
  14. Neuroglobin, cytoglobin, and a novel, eye-specific globin from chicken. Kugelstadt D, Haberkamp M, Hankeln T, Burmester T. Biochem. Biophys. Res. Commun. 325 719-725 (2004)
  15. 17β-Oestradiol anti-inflammatory effects in primary astrocytes require oestrogen receptor β-mediated neuroglobin up-regulation. De Marinis E, Acaz-Fonseca E, Arevalo MA, Ascenzi P, Fiocchetti M, Marino M, Garcia-Segura LM. J. Neuroendocrinol. 25 260-270 (2013)
  16. Does neuroglobin protect neurons from ischemic insult? A quantitative investigation of neuroglobin expression following transient MCAo in spontaneously hypertensive rats. Hundahl C, Kelsen J, Kjaer K, Rønn LC, Weber RE, Geuens E, Hay-Schmidt A, Nyengaard JR. Brain Res. 1085 19-27 (2006)
  17. Neuroglobin and other hexacoordinated hemoglobins show a weak temperature dependence of oxygen binding. Uzan J, Dewilde S, Burmester T, Hankeln T, Moens L, Hamdane D, Marden MC, Kiger L. Biophys. J. 87 1196-1204 (2004)
  18. Old proteins - new locations: myoglobin, haemoglobin, neuroglobin and cytoglobin in solid tumours and cancer cells. Gorr TA, Wichmann D, Pilarsky C, Theurillat JP, Fabrizius A, Laufs T, Bauer T, Koslowski M, Horn S, Burmester T, Hankeln T, Kristiansen G. Acta Physiol (Oxf) 202 563-581 (2011)
  19. Neuroglobin overexpression in cultured human neuronal cells protects against hydrogen peroxide insult via activating phosphoinositide-3 kinase and opening the mitochondrial K(ATP) channel. Antao ST, Duong TT, Aran R, Witting PK. Antioxid. Redox Signal. 13 769-781 (2010)
  20. The structural dynamics of myoglobin. Brunori M, Bourgeois D, Vallone B. J. Struct. Biol. 147 223-234 (2004)
  21. Factors controlling the reactivity of hydrogen sulfide with hemeproteins. Pietri R, Lewis A, León RG, Casabona G, Kiger L, Yeh SR, Fernandez-Alberti S, Marden MC, Cadilla CL, López-Garriga J. Biochemistry 48 4881-4894 (2009)
  22. When the brain goes diving: glial oxidative metabolism may confer hypoxia tolerance to the seal brain. Mitz SA, Reuss S, Folkow LP, Blix AS, Ramirez JM, Hankeln T, Burmester T. Neuroscience 163 552-560 (2009)
  23. 17β-estradiol--a new modulator of neuroglobin levels in neurons: role in neuroprotection against H₂O₂-induced toxicity. De Marinis E, Ascenzi P, Pellegrini M, Galluzzo P, Bulzomi P, Arevalo MA, Garcia-Segura LM, Marino M. Neurosignals 18 223-235 (2010)
  24. Cellular protection from oxidative DNA damage by over-expression of the novel globin cytoglobin in vitro. Hodges NJ, Innocent N, Dhanda S, Graham M. Mutagenesis 23 293-298 (2008)
  25. Neuroprotective function of human neuroglobin is correlated with its guanine nucleotide dissociation inhibitor activity. Watanabe S, Wakasugi K. Biochem. Biophys. Res. Commun. 369 695-700 (2008)
  26. Residues in the distal heme pocket of neuroglobin. Implications for the multiple ligand binding steps. Uno T, Ryu D, Tsutsumi H, Tomisugi Y, Ishikawa Y, Wilkinson AJ, Sato H, Hayashi T. J Biol Chem 279 5886-5893 (2004)
  27. Neuroglobin: enzymatic reduction and oxygen affinity. Giuffrè A, Moschetti T, Vallone B, Brunori M. Biochem. Biophys. Res. Commun. 367 893-898 (2008)
  28. The binding of cytochrome c to neuroglobin: a docking and surface plasmon resonance study. Bønding SH, Henty K, Dingley AJ, Brittain T. Int. J. Biol. Macromol. 43 295-299 (2008)
  29. The reactions of neuroglobin with CO: evidence for two forms of the ferrous protein. Fago A, Mathews AJ, Dewilde S, Moens L, Brittain T. J. Inorg. Biochem. 100 1339-1343 (2006)
  30. Mapping protein matrix cavities in human cytoglobin through Xe atom binding. de Sanctis D, Dewilde S, Pesce A, Moens L, Ascenzi P, Hankeln T, Burmester T, Bolognesi M. Biochem. Biophys. Res. Commun. 316 1217-1221 (2004)
  31. Neuron-specific expression of neuroglobin in mammals. Laufs TL, Wystub S, Reuss S, Burmester T, Saaler-Reinhardt S, Hankeln T. Neurosci. Lett. 362 83-86 (2004)
  32. Bishistidyl heme hexacoordination, a key structural property in Drosophila melanogaster hemoglobin. de Sanctis D, Dewilde S, Vonrhein C, Pesce A, Moens L, Ascenzi P, Hankeln T, Burmester T, Ponassi M, Nardini M, Bolognesi M. J Biol Chem 280 27222-27229 (2005)
  33. Molecular dynamics simulation of deoxy and carboxy murine neuroglobin in water. Anselmi M, Brunori M, Vallone B, Di Nola A. Biophys. J. 93 434-441 (2007)
  34. Neuroglobin and cytoglobin as potential enzyme or substrate. Trandafir F, Hoogewijs D, Altieri F, Rivetti di Val Cervo P, Ramser K, Van Doorslaer S, Vanfleteren JR, Moens L, Dewilde S. Gene 398 103-113 (2007)
  35. Effect of the N-terminus on heme cavity structure, ligand equilibrium, rate constants, and reduction potentials of nitrophorin 2 from Rhodnius prolixus. Berry RE, Shokhireva TKh, Filippov I, Shokhirev MN, Zhang H, Walker FA. Biochemistry 46 6830-6843 (2007)
  36. Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain. Winter MB, Herzik MA, Kuriyan J, Marletta MA. Proc. Natl. Acad. Sci. U.S.A. 108 E881-9 (2011)
  37. Exploring the molecular basis of heme coordination in human neuroglobin. Nadra AD, Martí MA, Pesce A, Bolognesi M, Estrin DA. Proteins 71 695-705 (2008)
  38. Hyperthermal stability of neuroglobin and cytoglobin. Hamdane D, Kiger L, Dewilde S, Uzan J, Burmester T, Hankeln T, Moens L, Marden MC. FEBS J. 272 2076-2084 (2005)
  39. Neuroglobin genetic polymorphisms and their relationship to functional outcomes after traumatic brain injury. Chuang PY, Conley YP, Poloyac SM, Okonkwo DO, Ren D, Sherwood PR, Hravnak M, Alexander SA. J. Neurotrauma 27 999-1006 (2010)
  40. Characterization of nonsymbiotic tomato hemoglobin. Ioanitescu AI, Dewilde S, Kiger L, Marden MC, Moens L, Van Doorslaer S. Biophys. J. 89 2628-2639 (2005)
  41. The oxidation process of Antarctic fish hemoglobins. Vitagliano L, Bonomi G, Riccio A, di Prisco G, Smulevich G, Mazzarella L. Eur. J. Biochem. 271 1651-1659 (2004)
  42. Abacavir modulates peroxynitrite-mediated oxidation of ferrous nitrosylated human serum heme-albumin. Ascenzi P, Fasano M. Biochem. Biophys. Res. Commun. 353 469-474 (2007)
  43. Coupling of the heme and an internal disulfide bond in human neuroglobin. Hamdane D, Kiger L, Dewilde S, Green BN, Pesce A, Uzan J, Burmester T, Hankeln T, Bolognesi M, Moens L, Marden MC. Micron 35 59-62 (2004)
  44. Thr-E11 regulates O2 affinity in Cerebratulus lacteus mini-hemoglobin. Pesce A, Nardini M, Ascenzi P, Geuens E, Dewilde S, Moens L, Bolognesi M, Riggs AF, Hale A, Deng P, Nienhaus GU, Olson JS, Nienhaus K. J. Biol. Chem. 279 33662-33672 (2004)
  45. An X-ray diffraction and X-ray absorption spectroscopy joint study of neuroglobin. Arcovito A, Moschetti T, D'Angelo P, Mancini G, Vallone B, Brunori M, Della Longa S. Arch. Biochem. Biophys. 475 7-13 (2008)
  46. The structure of neuroglobin at high Xe and Kr pressure reveals partial conservation of globin internal cavities. Moschetti T, Mueller U, Schulze J, Brunori M, Vallone B. Biophys. J. 97 1700-1708 (2009)
  47. Reductive nitrosylation and peroxynitrite-mediated oxidation of heme-hemopexin. Ascenzi P, Bocedi A, Antonini G, Bolognesi M, Fasano M. FEBS J. 274 551-562 (2007)
  48. Structure and properties of a bis-histidyl ligated globin from Caenorhabditis elegans. Yoon J, Herzik MA, Winter MB, Tran R, Olea C, Marletta MA. Biochemistry 49 5662-5670 (2010)
  49. The anti-apoptotic role of neuroglobin. Brittain T. Cells 1 1133-1155 (2012)
  50. The globin gene family of the cephalochordate amphioxus: implications for chordate globin evolution. Ebner B, Panopoulou G, Vinogradov SN, Kiger L, Marden MC, Burmester T, Hankeln T. BMC Evol. Biol. 10 370 (2010)
  51. The strength of EPR and ENDOR techniques in revealing structure-function relationships in metalloproteins. Van Doorslaer S, Vinck E. Phys Chem Chem Phys 9 4620-4638 (2007)
  52. Gene expression and tissue distribution of cytoglobin and myoglobin in the Amphibia and Reptilia: possible compensation of myoglobin with cytoglobin in skeletal muscle cells of anurans that lack the myoglobin gene. Xi Y, Obara M, Ishida Y, Ikeda S, Yoshizato K. Gene 398 94-102 (2007)
  53. Molecular dynamics simulation of the neuroglobin crystal: comparison with the simulation in solution. Anselmi M, Brunori M, Vallone B, Di Nola A. Biophys. J. 95 4157-4162 (2008)
  54. Neuroglobin and cytoglobin: Two new entries in the hemoglobin superfamily*. Ascenzi P, Bocedi A, de Sanctis D, Pesce A, Bolognesi M, Marden MC, Dewilde S, Moens L, Hankeln T, Burmester T. Biochem Mol Biol Educ 32 305-313 (2004)
  55. Preparation and characterization of a chimeric zebrafish-human neuroglobin engineered by module substitution. Wakasugi K, Morishima I. Biochem. Biophys. Res. Commun. 330 591-597 (2005)
  56. The human brain hexacoordinated neuroglobin three-dimensional structure. Pesce A, Dewilde S, Nardini M, Moens L, Ascenzi P, Hankeln T, Burmester T, Bolognesi M. Micron 35 63-65 (2004)
  57. The crystal structure of wild-type human brain neuroglobin reveals flexibility of the disulfide bond that regulates oxygen affinity. Guimarães BG, Hamdane D, Lechauve C, Marden MC, Golinelli-Pimpaneau B. Acta Crystallogr. D Biol. Crystallogr. 70 1005-1014 (2014)
  58. A redox signalling globin is essential for reproduction in Caenorhabditis elegans. De Henau S, Tilleman L, Vangheel M, Luyckx E, Trashin S, Pauwels M, Germani F, Vlaeminck C, Vanfleteren JR, Bert W, Pesce A, Nardini M, Bolognesi M, De Wael K, Moens L, Dewilde S, Braeckman BP. Nat Commun 6 8782 (2015)
  59. Abacavir and warfarin modulate allosterically kinetics of NO dissociation from ferrous nitrosylated human serum heme-albumin. Ascenzi P, Imperi F, Coletta M, Fasano M. Biochem. Biophys. Res. Commun. 369 686-691 (2008)
  60. Disulfide bonds regulate binding of exogenous ligand to human cytoglobin. Tsujino H, Yamashita T, Nose A, Kukino K, Sawai H, Shiro Y, Uno T. J. Inorg. Biochem. 135 20-27 (2014)
  61. Hell's Gate globin I: an acid and thermostable bacterial hemoglobin resembling mammalian neuroglobin. Teh AH, Saito JA, Baharuddin A, Tuckerman JR, Newhouse JS, Kanbe M, Newhouse EI, Rahim RA, Favier F, Didierjean C, Sousa EH, Stott MB, Dunfield PF, Gonzalez G, Gilles-Gonzalez MA, Najimudin N, Alam M. FEBS Lett. 585 3250-3258 (2011)
  62. Neuroglobin over expressing mice: expression pattern and effect on brain ischemic infarct size. Raida Z, Hundahl CA, Nyengaard JR, Hay-Schmidt A. PLoS ONE 8 e76565 (2013)
  63. Non-covalent and covalent modifications modulate the reactivity of monomeric mammalian globins. Ascenzi P, Marino M, Polticelli F, Coletta M, Gioia M, Marini S, Pesce A, Nardini M, Bolognesi M, Reeder BJ, Wilson MT. Biochim. Biophys. Acta 1834 1750-1756 (2013)
  64. Structural insights into a low-spin myoglobin variant with bis-histidine coordination from molecular modeling. Lin YW. Proteins 79 679-684 (2011)
  65. Is neuroglobin a signal transducer? Giuffrè A, Moschetti T, Vallone B, Brunori M. IUBMB Life 60 410-413 (2008)
  66. Isoniazid inhibits the heme-based reactivity of Mycobacterium tuberculosis truncated hemoglobin N. Ascenzi P, Coletta A, Cao Y, Trezza V, Leboffe L, Fanali G, Fasano M, Pesce A, Ciaccio C, Marini S, Coletta M. PLoS ONE 8 e69762 (2013)
  67. Neuroglobin as a regulator of mitochondrial-dependent apoptosis: a bioinformatics analysis. Guidolin D, Agnati LF, Tortorella C, Marcoli M, Maura G, Albertin G, Fuxe K. Int. J. Mol. Med. 33 111-116 (2014)
  68. Letter Probing the role of the internal disulfide bond in regulating conformational dynamics in neuroglobin. Astudillo L, Bernad S, Derrien V, Sebban P, Miksovska J. Biophys. J. 99 L16-8 (2010)
  69. Rational design of heterodimeric protein using domain swapping for myoglobin. Lin YW, Nagao S, Zhang M, Shomura Y, Higuchi Y, Hirota S. Angew. Chem. Int. Ed. Engl. 54 511-515 (2015)
  70. The "icefish paradox." Which is the task of neuroglobin in Antarctic hemoglobin-less icefish? Cheng CH, di Prisco G, Verde C. IUBMB Life 61 184-188 (2009)
  71. Analyzing heme proteins using EPR techniques: the heme-pocket structure of ferric mouse neuroglobin. Vinck E, Van Doorslaer S, Dewilde S, Mitrikas G, Schweiger A, Moens L. J. Biol. Inorg. Chem. 11 467-475 (2006)
  72. Comparative genomics of neuroglobin reveals its early origins. Dröge J, Pande A, Englander EW, Makałowski W. PLoS ONE 7 e47972 (2012)
  73. The expression of neuroglobin in astrocytoma. Qin H, Guo Y, Zhang C, Zhang L, Li M, Guan P. Brain Tumor Pathol 29 10-16 (2012)
  74. Miniaturized heme proteins: crystal structure of Co(III)-mimochrome IV. Di Costanzo L, Geremia S, Randaccio L, Nastri F, Maglio O, Lombardi A, Pavone V. J. Biol. Inorg. Chem. 9 1017-1027 (2004)
  75. Sequencing of hemoglobin gene 4 (dmhb4) and Southern blot analysis provide evidence of more than four members of the Daphnia magna globin family. Nunes F, Spiering D, Wolf M, Wendler A, Pirow R, Paul RJ. Biosci. Biotechnol. Biochem. 69 1193-1197 (2005)
  76. Ferric human neuroglobin scavenges superoxide to form oxy adduct. Yamashita T, Hafsi L, Masuda E, Tsujino H, Uno T. Chem Pharm Bull (Tokyo) 62 613-615 (2014)
  77. Neuroglobin - a potential biological marker of retinal damage induced by LED light. Yu ZL, Qiu S, Chen XC, Dai ZH, Huang YC, Li YN, Cai RH, Lei HT, Gu HY. Neuroscience 270 158-167 (2014)
  78. Nitrosylation mechanisms of Mycobacterium tuberculosis and Campylobacter jejuni truncated hemoglobins N, O, and P. Ascenzi P, di Masi A, Tundo GR, Pesce A, Visca P, Coletta M. PLoS ONE 9 e102811 (2014)
  79. Reductive nitrosylation of the cardiolipin-ferric cytochrome c complex. Ascenzi P, Marino M, Ciaccio C, Santucci R, Coletta M. IUBMB Life 66 438-447 (2014)
  80. Solution 1H NMR characterization of the axial bonding of the two His in oxidized human cytoglobin. Bondarenko V, Dewilde S, Moens L, La Mar GN. J. Am. Chem. Soc. 128 12988-12999 (2006)
  81. *NO dissociation represents the rate limiting step for O2-mediated oxidation of ferrous nitrosylated Mycobacterium leprae truncated hemoglobin O. Ascenzi P, Bolognesi M, Visca P. Biochem. Biophys. Res. Commun. 357 809-814 (2007)
  82. Letter Cold-adapted Antarctic fish: the discovery of neuroglobin in the dominant suborder Notothenioidei. Cheng CH, di Prisco G, Verde C. Gene 433 100-101 (2009)
  83. Distal mutation modulates the heme sliding in mouse neuroglobin investigated by molecular dynamics simulation. Xu J, Yin G, Du W. Proteins 79 191-202 (2011)
  84. Extended survival of SH-SY5Y cells following overexpression of Lys67Glu neuroglobin is associated with stabilization of ΔψM. Skommer J, Brittain T. Cytometry A 81 602-610 (2012)
  85. Ligand orientation of human neuroglobin obtained from solution NMR and molecular dynamics simulation as compared with X-ray crystallography. Xu J, Li L, Yin G, Li H, Du W. J. Inorg. Biochem. 103 1693-1701 (2009)
  86. Solution 1H NMR study of the active site structure for the double mutant H64Q/V68F cyanide complex from mouse neuroglobin. Yin G, Li Y, Li J, Li J, Du W, Wei Q, Fang W. Biophys. Chem. 136 115-123 (2008)
  87. Structural identification of spectroscopic substates in neuroglobin. Nienhaus K, Lutz S, Meuwly M, Nienhaus GU. Chemphyschem 11 119-129 (2010)
  88. Two distinct heme distal site states define Cerebratulus lacteus mini-hemoglobin oxygen affinity. Martí MA, Bikiel DE, Crespo A, Nardini M, Bolognesi M, Estrin DA. Proteins 62 641-648 (2006)
  89. A distal ligand mutes the interaction of hydrogen sulfide with human neuroglobin. Ruetz M, Kumutima J, Lewis BE, Filipovic MR, Lehnert N, Stemmler TL, Banerjee R. J. Biol. Chem. 292 6512-6528 (2017)
  90. Expression and cell distribution of neuroglobin in the brain tissue after experimental subarachnoid hemorrhage in rats: a pilot study. Li WD, Sun Q, Zhang XS, Wang CX, Li S, Li W, Hang CH. Cell. Mol. Neurobiol. 34 247-255 (2014)
  91. Is the heme pocket region modulated by disulfide-bridge formation in fish and amphibian neuroglobins as in humans? Van Leuven W, Cuypers B, Desmet F, Giordano D, Verde C, Moens L, Van Doorslaer S, Dewilde S. Biochim. Biophys. Acta 1834 1757-1763 (2013)
  92. Molecular dynamics simulation of a carboxy murine neuroglobin mutated on the proximal side: heme displacement and concomitant rearrangement in loop regions. Xu J, Yin G, Huang F, Wang B, Du W. J Mol Model 16 759-770 (2010)
  93. The bis-histidyl complex in hemoproteins: A detailed conformational analysis of database protein structures and the case of Antarctic fish hemoglobins. Merlino A, Vergara A, Sica F, Mazzarella L. Mar Genomics 2 51-56 (2009)
  94. A spectroscopic study of structural heterogeneity and carbon monoxide binding in neuroglobin. Nienhaus K, Nienhaus GU. J Biol Phys 31 417-432 (2005)
  95. Computational evidence support the hypothesis of neuroglobin also acting as an electron transfer species. Paltrinieri L, Di Rocco G, Battistuzzi G, Borsari M, Sola M, Ranieri A, Zanetti-Polzi L, Daidone I, Bortolotti CA. J. Biol. Inorg. Chem. 22 615-623 (2017)
  96. Conformational stability of neuroglobin helix F--possible effects on the folding pathway within the globin family. Codutti L, Picotti P, Marin O, Dewilde S, Fogolari F, Corazza A, Viglino P, Moens L, Esposito G, Fontana A. FEBS J. 276 5177-5190 (2009)
  97. Ferric microperoxidase-11 catalyzes peroxynitrite isomerization. Ascenzi P, Leboffe L, Santucci R, Coletta M. J. Inorg. Biochem. 144 56-61 (2015)
  98. Molecular dynamics simulation of carboxy and deoxy human cytoglobin in solution. Zhang B, Xu J, Li Y, Du W, Fang W. J. Inorg. Biochem. 105 949-956 (2011)
  99. Reductive nitrosylation of Methanosarcina acetivorans protoglobin: a comparative study. Ascenzi P, Pesce A, Nardini M, Bolognesi M, Ciaccio C, Coletta M, Dewilde S. Biochem. Biophys. Res. Commun. 430 1301-1305 (2013)
  100. Structure and dynamics of Antarctic fish neuroglobin assessed by computer simulations. Boron I, Russo R, Boechi L, Cheng CH, di Prisco G, Estrin DA, Verde C, Nadra AD. IUBMB Life 63 206-213 (2011)
  101. Interaction of apoNeuroglobin with heme-Aβ complexes relevant to Alzheimer's disease. Seal M, Uppal S, Kundu S, Dey SG. J. Biol. Inorg. Chem. 20 563-574 (2015)
  102. Ligand binding, reactivity and biological activity of a distal pocket mutant of neuroglobin. Skommer J, Helbo S, Henty K, Brittain T. Int. J. Biol. Macromol. 51 284-290 (2012)
  103. Loss of Neuroglobin Expression Alters Cdkn1a/Cdk6-Expression Resulting in Increased Proliferation of Neural Stem Cells. Luyckx E, Van Leuven W, Andre D, Quarta A, Reekmans K, Fransen E, Moens L, Hankeln T, Ponsaerts P, Dewilde S. Stem Cells Dev. 27 378-390 (2018)
  104. Spectroscopic studies on unfolding processes of apo-neuroglobin induced by guanidine hydrochloride and urea. Zhang C, Gao C, Mu J, Qiu Z, Li L. Biomed Res Int 2013 349542 (2013)
  105. EPR analysis of cyanide complexes of wild-type human neuroglobin and mutants in comparison to horse heart myoglobin. Van Doorslaer S, Trandafir F, Harmer JR, Moens L, Dewilde S. Biophys. Chem. 190-191 8-16 (2014)
  106. Modulation of oxygen binding to insect hemoglobins: the structure of hemoglobin from the botfly Gasterophilus intestinalis. Pesce A, Nardini M, Dewilde S, Hoogewijs D, Ascenzi P, Moens L, Bolognesi M. Protein Sci. 14 3057-3063 (2005)
  107. NO2(-)-mediated nitrosylation of ferrous microperoxidase-11. Ascenzi P, Sbardella D, Fiocchetti M, Santucci R, Coletta M. J. Inorg. Biochem. 153 121-127 (2015)
  108. Open and Lys-His Hexacoordinated Closed Structures of a Globin with Swapped Proximal and Distal Sites. Teh AH, Saito JA, Najimudin N, Alam M. Sci Rep 5 11407 (2015)
  109. Preliminary crystallographic characterization of PrnB, the second enzyme in the pyrrolnitrin biosynthetic pathway. De Laurentis W, Leang K, Hahn K, Podemski B, Adam A, Kroschwald S, Carter LG, van Pee KH, Naismith JH. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 62 1134-1137 (2006)
  110. Revised CHARMM force field parameters for iron-containing cofactors of photosystem II. Adam S, Knapp-Mohammady M, Yi J, Bondar AN. J Comput Chem 39 7-20 (2018)
  111. Structural characterization of spectroscopic substates in carbonmonoxy neuroglobin. Lutz S, Meuwly M. Faraday Discuss. 150 375-90; discussion 391-418 (2011)
  112. Research Support, Non-U.S. Gov't Crystal structure of Kumaglobin: a hexacoordinated heme protein from an anhydrobiotic tardigrade, Ramazzottius varieornatus. Kim J, Fukuda Y, Inoue T. FEBS J 286 1287-1304 (2019)
  113. Exploiting a list of protein sequences. Marden MC, Dewilde S, Kiger L, Hamdane D, Uzan J, Burmester T, Hankeln T, Moens L, Baudin-Creuza V, Celier C, Wajcman H. Gene 398 35-41 (2007)
  114. Impact of A90P, F106L and H64V mutations on neuroglobin stability and ligand binding kinetics. André E, Derrien V, Sebban P, Assrir N, Lescop E, Bernad S. J Biol Inorg Chem 24 39-52 (2019)
  115. Reductive nitrosylation of ferric human hemoglobin bound to human haptoglobin 1-1 and 2-2. Ascenzi P, De Simone G, Polticelli F, Gioia M, Coletta M. J. Biol. Inorg. Chem. 23 437-445 (2018)
  116. Antarctic fish versus human cytoglobins - The same but yet so different. Cuypers B, Vermeylen S, Hammerschmid D, Trashin S, Rahemi V, Konijnenberg A, De Schutter A, Cheng CC, Giordano D, Verde C, De Wael K, Sobott F, Dewilde S, Van Doorslaer S. J. Inorg. Biochem. 173 66-78 (2017)
  117. Hemoproteins in the cold. Verde C, Giordano D, Russo R, Riccio A, Vergara A, Mazzarella L, di Prisco G. Mar Genomics 2 67-73 (2009)
  118. Hydrogen peroxide induces heme degradation and protein aggregation in human neuroglobin: roles of the disulfide bridge and hydrogen-bonding in the distal heme cavity. Di Rocco G, Bernini F, Battistuzzi G, Ranieri A, Bortolotti CA, Borsari M, Sola M. FEBS J 290 148-161 (2023)
  119. Molecular dynamics study of hell's gate globin I (HGbI) from a methanotrophic extremophile: oxygen migration through a large cavity. Newhouse EI, Newhouse JS, Alam M. J Mol Model 19 2265-2271 (2013)
  120. Neuroglobin is capable of self-oxidation of methionine64 introduced at the heme axial position. Liu HX, Li L, He B, Gao SQ, Wen GB, Lin YW. Dalton Trans 47 10847-10852 (2018)
  121. Structural and functional properties of Antarctic fish cytoglobins-1: Cold-reactivity in multi-ligand reactions. Giordano D, Pesce A, Vermeylen S, Abbruzzetti S, Nardini M, Marchesani F, Berghmans H, Seira C, Bruno S, Javier Luque F, di Prisco G, Ascenzi P, Dewilde S, Bolognesi M, Viappiani C, Verde C. Comput Struct Biotechnol J 18 2132-2144 (2020)
  122. Structure of Yak Lactoperoxidase at 1.55 Å Resolution. Viswanathan V, Rani C, Ahmad N, Singh PK, Sharma P, Kaur P, Sharma S, Singh TP. Protein J 40 8-18 (2021)
  123. The nitrite reductase activity of horse heart carboxymethylated-cytochrome c is modulated by cardiolipin. Ascenzi P, Sbardella D, Sinibaldi F, Santucci R, Coletta M. J. Biol. Inorg. Chem. 21 421-432 (2016)
  124. Utility of fluorescent heme analogue ZnPPIX to monitor conformational heterogeneity in vertebrate hexa-coordinated globins. Tangar A, Derrien V, Lei R, Santiago Estevez MJ, Sebban P, Bernad S, Miksovska J. Metallomics 11 906-913 (2019)


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