X-ray diffraction
2.1Å resolution

Nonproductive and Novel Binding Modes in Cytotoxic Ribonucleases from Rana catesbeiana of Two Crystal Structures Complexed with (2,5 CpG) and d(ApCpGpA)

Source organism: Rana catesbeiana
Entry authors: Tsai C-J, Liu J-H, Liao Y-D, Chen L-y, Cheng P-T, Sun Y-J

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
RNAse_Pc domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 105 amino acids
Theoretical weight: 12.19 KDa
Source organism: Rana catesbeiana
  • Canonical: Q9DFY5 (Residues: 24-128; Coverage: 100%)
Sequence domains: Pancreatic ribonuclease
Structure domains: Ribonuclease A-like domain

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P43212
Unit cell:
a: 61.8Å b: 61.8Å c: 65.96Å
α: 90° β: 90° γ: 90°
R R work R free
0.203 0.203 0.251