› › Function and Biology

The Molecular Basis of Vitamin E Retention: Structure of Human Alpha-Tocopherol Transfer Protein

Source organism: Homo sapiens
Biochemical function: phosphatidylinositol bisphosphate binding
Biological process: positive regulation of amyloid-beta clearance
Cellular component: cytosol

Quick links

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00650
Domain description: CRAL/TRIO domain
Occurring in:
  1. Alpha-tocopherol transfer protein
The deposited structure of PDB entry 1oip contains 1 copy of Pfam domain PF00650 (CRAL/TRIO domain) in Alpha-tocopherol transfer protein. Showing 1 copy in chain A.

PF03765
Domain description: CRAL/TRIO, N-terminal domain
Occurring in:
  1. Alpha-tocopherol transfer protein
The deposited structure of PDB entry 1oip contains 1 copy of Pfam domain PF03765 (CRAL/TRIO, N-terminal domain) in Alpha-tocopherol transfer protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001251
Domain description: CRAL-TRIO lipid binding domain
Occurring in:
  1. Alpha-tocopherol transfer protein
IPR036865
Domain description: CRAL-TRIO lipid binding domain superfamily
Occurring in:
  1. Alpha-tocopherol transfer protein
IPR011074
Domain description: CRAL/TRIO, N-terminal domain
Occurring in:
  1. Alpha-tocopherol transfer protein
IPR036273
Domain description: CRAL/TRIO, N-terminal domain superfamily
Occurring in:
  1. Alpha-tocopherol transfer protein

Structure domains

CATH CATH domains
1.20.5.1200
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homology: Alpha-tocopherol transfer
Occurring in:
  1. Alpha-tocopherol transfer protein
The deposited structure of PDB entry 1oip contains 1 copy of CATH domain 1.20.5.1200 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces) in Alpha-tocopherol transfer protein. Showing 1 copy in chain A.
3.40.525.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Phosphatidylinositol Transfer Protein Sec14p
Homology: CRAL-TRIO lipid binding domain
Occurring in:
  1. Alpha-tocopherol transfer protein
The deposited structure of PDB entry 1oip contains 1 copy of CATH domain 3.40.525.10 (Phosphatidylinositol Transfer Protein Sec14p) in Alpha-tocopherol transfer protein. Showing 1 copy in chain A.
1.10.8.20
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Helicase, Ruva Protein; domain 3
Homology: N-terminal domain of phosphatidylinositol transfer protein sec14p
Occurring in:
  1. Alpha-tocopherol transfer protein
The deposited structure of PDB entry 1oip contains 1 copy of CATH domain 1.10.8.20 (Helicase, Ruva Protein; domain 3) in Alpha-tocopherol transfer protein. Showing 1 copy in chain A.
SCOP SCOP annotations
52088
Class: Alpha and beta proteins (a/b)
Fold: SpoIIaa-like
Superfamily: CRAL/TRIO domain
Occurring in:
  1. Alpha-tocopherol transfer protein
The deposited structure of PDB entry 1oip contains 1 copy of SCOP domain 52088 (CRAL/TRIO domain) in Alpha-tocopherol transfer protein. Showing 1 copy in chain A.
46939
Class: All alpha proteins
Fold: RuvA C-terminal domain-like
Superfamily: CRAL/TRIO N-terminal domain
Occurring in:
  1. Alpha-tocopherol transfer protein
The deposited structure of PDB entry 1oip contains 1 copy of SCOP domain 46939 (CRAL/TRIO N-terminal domain) in Alpha-tocopherol transfer protein. Showing 1 copy in chain A.

Quick links