X-ray diffraction
1.5Å resolution

The Crystal Structure of Phosphopantetheine adenylyltransferase from Thermus Thermophilus in complex with 4'-phosphopantetheine


Function and Biology Details

Reaction catalysed:
ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Phosphopantetheine adenylyltransferase Chain: A
Molecule details ›
Chain: A
Length: 160 amino acids
Theoretical weight: 17.73 KDa
Source organism: Thermus thermophilus HB8
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q5SJS9 (Residues: 1-160; Coverage: 100%)
Gene names: TTHA0929, coaD
Sequence domains: Cytidylyltransferase-like
Structure domains: HUPs

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL26B1
Spacegroup: R32
Unit cell:
a: 115.715Å b: 115.715Å c: 115.661Å
α: 90° β: 90° γ: 120°
R R work R free
0.196 0.196 0.201
Expression system: Escherichia coli BL21(DE3)