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LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A POST-TRANSFER EDITING SUBSTRATE ANALOGUE

Source organism: Thermus thermophilus HB27
Biochemical function: metal ion binding
Biological process: aminoacyl-tRNA metabolism involved in translational fidelity
Cellular component: cytosol

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EC 6.1.1.4: Leucine--tRNA ligase

Reaction catalysed:
ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)
Systematic name:
L-leucine:tRNA(Leu) ligase (AMP-forming)
Alternative Name(s):
  • Leucine translase
  • Leucine-tRNA synthetase
  • Leucyl-tRNA synthetase
  • Leucyl-transfer RNA synthetase
  • Leucyl-transfer ribonucleate synthetase
  • Leucyl-transfer ribonucleic acid synthetase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF08264
Domain description: Anticodon-binding domain of tRNA ligase
Occurring in:
  1. Leucine--tRNA ligase
The deposited structure of PDB entry 1obc contains 1 copy of Pfam domain PF08264 (Anticodon-binding domain of tRNA ligase) in Leucine--tRNA ligase. Showing 1 copy in chain A.

PF14795
Domain description: Leucine-tRNA synthetase-specific domain
Occurring in:
  1. Leucine--tRNA ligase
The deposited structure of PDB entry 1obc contains 1 copy of Pfam domain PF14795 (Leucine-tRNA synthetase-specific domain) in Leucine--tRNA ligase. Showing 1 copy in chain A.

PF00133
Domain description: tRNA synthetases class I (I, L, M and V)
Occurring in:
  1. Leucine--tRNA ligase
The deposited structure of PDB entry 1obc contains 1 copy of Pfam domain PF00133 (tRNA synthetases class I (I, L, M and V)) in Leucine--tRNA ligase. Showing 1 copy in chain A.

PF13603
Domain description: Leucyl-tRNA synthetase, editing domain
Occurring in:
  1. Leucine--tRNA ligase
The deposited structure of PDB entry 1obc contains 1 copy of Pfam domain PF13603 (Leucyl-tRNA synthetase, editing domain) in Leucine--tRNA ligase. Showing 1 copy in chain A.

PF09334
Domain description: tRNA synthetases class I (M)
Occurring in:
  1. Leucine--tRNA ligase
The deposited structure of PDB entry 1obc contains 1 copy of Pfam domain PF09334 (tRNA synthetases class I (M)) in Leucine--tRNA ligase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002302
Domain description: Leucine-tRNA ligase
Occurring in:
  1. Leucine--tRNA ligase
IPR014729
Domain description: Rossmann-like alpha/beta/alpha sandwich fold
Occurring in:
  1. Leucine--tRNA ligase
IPR002300
Domain description: Aminoacyl-tRNA synthetase, class Ia
Occurring in:
  1. Leucine--tRNA ligase
IPR013155
Domain description: Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
Occurring in:
  1. Leucine--tRNA ligase
IPR009080
Domain description: Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
Occurring in:
  1. Leucine--tRNA ligase
IPR023356
Domain description: Leucyl-tRNA synthetase, domain 3
Occurring in:
  1. Leucine--tRNA ligase
IPR009008
Domain description: Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
Occurring in:
  1. Leucine--tRNA ligase
IPR025709
Domain description: Leucyl-tRNA synthetase, editing domain
Occurring in:
  1. Leucine--tRNA ligase
IPR001412
Domain description: Aminoacyl-tRNA synthetase, class I, conserved site
Occurring in:
  1. Leucine--tRNA ligase

Structure domains

CATH CATH domains
3.40.50.620
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: HUPs
Occurring in:
  1. Leucine--tRNA ligase
The deposited structure of PDB entry 1obc contains 1 copy of CATH domain 3.40.50.620 (Rossmann fold) in Leucine--tRNA ligase. Showing 1 copy in chain A.
1.10.730.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Isoleucyl-tRNA Synthetase; Domain 1
Homology: Isoleucyl-tRNA Synthetase; Domain 1
Occurring in:
  1. Leucine--tRNA ligase
The deposited structure of PDB entry 1obc contains 1 copy of CATH domain 1.10.730.10 (Isoleucyl-tRNA Synthetase; Domain 1) in Leucine--tRNA ligase. Showing 1 copy in chain A.
2.30.210.10
Class: Mainly Beta
Architecture: Roll
Topology: Leucyl-tRNA synthetase, domain 3
Homology: Leucyl-tRNA synthetase, domain 3
Occurring in:
  1. Leucine--tRNA ligase
The deposited structure of PDB entry 1obc contains 1 copy of CATH domain 2.30.210.10 (Leucyl-tRNA synthetase, domain 3) in Leucine--tRNA ligase. Showing 1 copy in chain A.
3.90.740.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Isoleucyl-tRNA Synthetase; domain 2
Homology: Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
Occurring in:
  1. Leucine--tRNA ligase
The deposited structure of PDB entry 1obc contains 1 copy of CATH domain 3.90.740.10 (Isoleucyl-tRNA Synthetase; domain 2) in Leucine--tRNA ligase. Showing 1 copy in chain A.
SCOP SCOP annotations
52375
Class: Alpha and beta proteins (a/b)
Fold: Adenine nucleotide alpha hydrolase-like
Superfamily: Nucleotidylyl transferase
Occurring in:
  1. Leucine--tRNA ligase
The deposited structure of PDB entry 1obc contains 1 copy of SCOP domain 52375 (Class I aminoacyl-tRNA synthetases (RS), catalytic domain) in Leucine--tRNA ligase. Showing 1 copy in chain A.
47324
Class: All alpha proteins
Fold: Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Superfamily: Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Occurring in:
  1. Leucine--tRNA ligase
The deposited structure of PDB entry 1obc contains 1 copy of SCOP domain 47324 (Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases) in Leucine--tRNA ligase. Showing 1 copy in chain A.
50678
Class: All beta proteins
Fold: ValRS/IleRS/LeuRS editing domain
Superfamily: ValRS/IleRS/LeuRS editing domain
Occurring in:
  1. Leucine--tRNA ligase
The deposited structure of PDB entry 1obc contains 1 copy of SCOP domain 50678 (ValRS/IleRS/LeuRS editing domain) in Leucine--tRNA ligase. Showing 1 copy in chain A.

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